Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8059658 | 0.80 | MAPT (0.61) | GBA1KDM4EMAPTALDH1A1PDE5A | |
| SCHEMBL8059487 | 0.80 | KDM1A (0.51) | GBA1KDM4EMAPTALDH1A1RPS6KB2 | |
| SCHEMBL8070560 | 0.80 | KDM4E (0.52) | GBA1KDM4EMAPTALDH1A1RPS6KB2 | |
| SCHEMBL19895346 | 0.76 | NPC1 (0.54) | GBA1MAPTPDE5AGAAHTT | |
| SCHEMBL8070339 | 0.75 | RPS6KB2 (0.57) | GBA1KDM4EMAPTALDH1A1RPS6KB2 | |
| SCHEMBL8059496 | 0.72 | PDE5A (0.42) | GBA1KDM4EMAPTALDH1A1RPS6KB2 | |
| SCHEMBL8059785 | 0.71 | KDM4E (0.55) | GBA1KDM4EMAPTALDH1A1GAA | |
| SCHEMBL14095195 | 0.71 | ADORA2A (0.50) | GBA1KDM4EMAPTALDH1A1RPS6KB2 | |
| SCHEMBL5026243 | 0.70 | KDM4E (0.48) | KDM4EMAPTALDH1A1RPS6KB2PDE5A | |
| SCHEMBL914097 | 0.69 | ALDH1A1 (0.81) | KDM4EMAPTALDH1A1GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6150372-A | IMMUNOINFLAMMATORY AND AUTOIMMUNE DISEASES; BLOCKING INTRACELLULAR SIGNAL TRANSDUCTION AND ACTIVATION OF TRANSCRIPTION FACTORS; KINASE INHIBITORS; ANTIARTHRITIC, ISCHEMIC AGENTS, MULTIPLE SCLEROSIS, TRANSPLANT REJECTION | SIGNAL PHARMACEUTICALS, INC. (US) | 2000-11-21 | — | — | US | disclosed |
| US-5939421-A | TREATMENT OF IMMUNOINFLAMMATORY AND AUTOIMMUNE DISEASES SUCH AS RHEUMATOID ARTHRITIS, TRANSPLANT REJECTION; INHIBIT KINASE(S) THAT REGULATE ACTIVATION OF TRANSCRIPTION FACTORS TO PREVENT PRODUCTION OF INFLAMMATORY PROTEINS | SIGNAL PHARMACEUTICALS, INC. (US) | 1999-08-17 | — | — | US | disclosed |
| WO-1999001441-A1 | QUINAZOLINE ANALOGS AND RELATED COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS | SIGNAL PHARMACEUTICALS, INC. (US) | 1999-01-14 | — | — | WO | disclosed |