Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.34 |
| ▸ | ATXN2 | Q99700 | 2/20 | 0.34 |
| ▸ | SCNN1A | P37088 | 5/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1684500 | 0.93 | SCNN1A (0.35) | ALDH1A1ENPP2ATXN2SCNN1A | |
| SCHEMBL1684511 | 0.93 | SCNN1A (0.35) | ALDH1A1ENPP2ATXN2SCNN1A | |
| SCHEMBL1684543 | 0.93 | SCNN1A (0.41) | ALDH1A1ENPP2ATXN2SCNN1A | |
| SCHEMBL1684608 | 0.92 | ALDH1A1 (0.42) | ALDH1A1KMT2AMEN1ENPP2ATXN2 | |
| SCHEMBL1684603 | 0.92 | ALDH1A1 (0.42) | ALDH1A1KMT2AMEN1ENPP2ATXN2 | |
| SCHEMBL1684527 | 0.91 | ALDH1A1 (0.44) | ALDH1A1GPBAR1KMT2AMEN1SCNN1A | |
| SCHEMBL1587241 | 0.91 | SCNN1A (0.36) | ALDH1A1KMT2AMEN1ENPP2ATXN2 | |
| SCHEMBL1587243 | 0.91 | SCNN1A (0.36) | ALDH1A1KMT2AMEN1ENPP2ATXN2 | |
| SCHEMBL19392998 | 0.90 | ALDH1A1 (0.41) | ALDH1A1KMT2AMEN1ENPP2ATXN2 | |
| SCHEMBL1684842 | 0.89 | ALDH1A1 (0.38) | ALDH1A1KMT2AMEN1ENPP2ATXN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012035158-A1 | PYRAZINE DERIVATIVES AS ENAC BLOCKERS | NOVARTIS AG (CH) | 2012-03-22 | — | — | WO | disclosed |