Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRR1 | P24046 | 5/20 | 0.45 |
| ▸ | GABRR2 | P28476 | 3/20 | 0.45 |
| ▸ | BLM | P54132 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | GABRR3 | A8MPY1 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.44 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.44 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | SUCNR1 | Q9BXA5 | 2/20 | 0.38 |
| ▸ | ABAT | P80404 | 1/20 | 0.38 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL6924407 | 0.86 | — | — | |
| SCHEMBL6534653 | 0.83 | — | — | |
| SCHEMBL37921 | 0.83 | — | — | |
| SCHEMBL30874993 | 0.83 | — | — | |
| Acetic Acid SCHEMBL5621001 | 0.83 | FFAR3 (0.44) | GABRR1GABRR2BLMLMNAGABRR3 | |
| Propionic Acid SCHEMBL4033717 | 0.81 | — | — | |
| Acrylic Acid SCHEMBL18260638 | 0.81 | — | — | |
| SCHEMBL9738638 | 0.79 | — | — | |
| Hydrochloric Acid SCHEMBL5838863 | 0.79 | — | — | |
| SCHEMBL1122022 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6079373-A | Gas engine with a gas fuel reforming device | ISUZU CERAMICS RESEARCH INSTITUTE CO., LTD. (JP) | 2000-06-27 | — | — | US | disclosed |
| EP-0878615-A2 | A gas engine with a gas fuel reforming device | ISUZU CERAMICS RESEARCH INSTITUTE CO., LTD. (JP) | 1998-11-18 | — | — | EP | disclosed |