Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 1/20 | 0.76 |
| ▸ | KDR | P35968 | 13/20 | 0.74 |
| ▸ | PDGFRA | P16234 | 11/20 | 0.74 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.61 |
| ▸ | AXL | P30530 | 1/20 | 0.59 |
| ▸ | SRC | P12931 | 1/20 | 0.58 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7482200 | 0.90 | FGFR2 (0.69) | FGFR2KDRPDGFRAAXLSRC | |
| SCHEMBL7479925 | 0.90 | FGFR2 (0.71) | FGFR2KDRPDGFRAPDGFRBAXL | |
| SCHEMBL7487378 | 0.89 | FGFR2 (0.77) | FGFR2KDRPDGFRAPDGFRBAXL | |
| SCHEMBL7481918 | 0.89 | FGFR2 (0.77) | FGFR2KDRPDGFRAPDGFRBSRC | |
| SCHEMBL29258974 | 0.89 | KDR (0.63) | FGFR2KDRPDGFRAPDGFRBAXL | |
| SCHEMBL7482801 | 0.88 | FGFR2 (0.76) | FGFR2KDRPDGFRAPDGFRBAXL | |
| SCHEMBL7487173 | 0.88 | FGFR2 (0.76) | FGFR2KDRPDGFRAPDGFRBAXL | |
| SCHEMBL7482620 | 0.88 | FGFR2 (0.76) | FGFR2KDRPDGFRAPDGFRBAXL | |
| SCHEMBL7482945 | 0.86 | FGFR2 (0.72) | FGFR2KDRPDGFRAPDGFRBAXL | |
| SCHEMBL842293 | 0.86 | FGFR2 (1.00) | FGFR2KDRPDGFRAPDGFRBSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6143764-A | ETHER DERIVATIVES OF QUINOLINE, ANTITUMOR AGENTS | KIRIN BEER KABUSHIKI KAISHA (JP) | 2000-11-07 | — | — | US | disclosed |
| EP-0860433-A1 | QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES INHIBITING AUTOPHOSPHORYLATION OF GROWTH FACTOR RECEPTOR ORIGINATING IN PLATELET AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 1998-08-26 | — | — | EP | disclosed |