Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCNN1A | P37088 | 10/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GHSR | Q92847 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.32 |
| ▸ | ATXN2 | Q99700 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL781518 | 0.95 | SCNN1A (0.45) | SCNN1AALDH1A1GHSRMEN1KMT2A | |
| SCHEMBL781520 | 0.95 | SCNN1A (0.45) | SCNN1AALDH1A1GHSRMEN1KMT2A | |
| SCHEMBL782165 | 0.93 | POLB (0.43) | SCNN1APOLBALDH1A1GHSR | |
| SCHEMBL782167 | 0.93 | POLB (0.43) | SCNN1APOLBALDH1A1GHSR | |
| SCHEMBL781835 | 0.93 | PLAU (0.35) | SCNN1AGHSR | |
| SCHEMBL781833 | 0.93 | PLAU (0.35) | SCNN1AGHSR | |
| SCHEMBL783212 | 0.92 | FKBP1A (0.37) | SCNN1APOLBALDH1A1MEN1KMT2A | |
| SCHEMBL783210 | 0.92 | FKBP1A (0.37) | SCNN1APOLBALDH1A1MEN1KMT2A | |
| SCHEMBL782976 | 0.92 | SCNN1A (0.34) | SCNN1APOLBALDH1A1GHSRMEN1 | |
| SCHEMBL782978 | 0.92 | SCNN1A (0.34) | SCNN1APOLBALDH1A1GHSRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012035158-A1 | PYRAZINE DERIVATIVES AS ENAC BLOCKERS | NOVARTIS AG (CH) | 2012-03-22 | — | — | WO | disclosed |