Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.41 |
| ▸ | MEN1 | O00255 | 6/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12920995 | 0.78 | KMT2A (0.49) | KMT2AMEN1ATMALDH1A1GAA | |
| SCHEMBL12920945 | 0.78 | KMT2A (0.53) | KMT2AMEN1ATMALDH1A1GAA | |
| SCHEMBL8070518 | 0.71 | KMT2A (0.44) | KMT2AMEN1ATMALDH1A1MAPT | |
| SCHEMBL3923891 | 0.69 | KMT2A (0.63) | KMT2AMEN1ATMALDH1A1POLB | |
| SCHEMBL4740056 | 0.65 | CACNA1B (0.38) | KMT2AMEN1 | |
| SCHEMBL4075272 | 0.64 | CNR2 (0.43) | ALDH1A1EPHX2 | |
| SCHEMBL5662464 | 0.64 | CNR2 (0.43) | ALDH1A1EPHX2 | |
| SCHEMBL12920954 | 0.61 | KMT2A (0.70) | KMT2AMEN1ATMALDH1A1 | |
| SCHEMBL5463448 | 0.60 | KMT2A (0.44) | KMT2AMEN1ATMALDH1A1 | |
| SCHEMBL22018065 | 0.59 | HTT (0.36) | KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009020580-A1 | GAMMA SECRETASE MODULATORS | SCHERING CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |