Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 18/20 | 0.57 |
| ▸ | PDE4A | P27815 | 9/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.57 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7436899 | 0.91 | PDE4B (0.68) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL5354647 | 0.90 | PDE4B (0.58) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL7624779 | 0.90 | PDE4B (0.58) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL14575649 | 0.89 | PDE4B (0.70) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL5359627 | 0.89 | PDE4B (0.70) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL5360475 | 0.89 | PDE4B (0.67) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL5360473 | 0.89 | PDE4B (0.67) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL5407368 | 0.89 | PDE4B (0.67) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL5755229 | 0.89 | PDE4B (0.67) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL5350320 | 0.86 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4DPDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0720600-B1 | 3-(3,4-DIOXYPHENYL)-PYRROLIDINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ICOS CORP (US) | 2000-07-12 | — | — | EP | disclosed |
| US-5665754-A | Substituted pyrrolidines | GLAXO WELLCOME INC. (US) | 1997-09-09 | — | — | US | disclosed |