Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 7/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.44 |
| ▸ | USP2 | O75604 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 7/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16158622 | 0.89 | CLK4 (0.41) | CLK4CYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL15906107 | 0.86 | AR (0.42) | CLK4CYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL3785940 | 0.85 | MET (0.43) | MAPK1 | |
| SCHEMBL7904615 | 0.85 | KIT (0.41) | CLK4CYP1A2CYP3A4CYP2C19ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3791236 | 0.84 | KIT (0.41) | CLK4CYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL4318363 | 0.81 | KIT (0.38) | CLK4CYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL3790853 | 0.74 | ABCG2 (0.43) | CLK4CYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL10440229 | 0.72 | CYP1A2 (0.41) | CLK4CYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL3786244 | 0.71 | PDE4D (0.42) | CLK4CYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL3797515 | 0.69 | CTSA (0.43) | CLK4CYP1A2CYP3A4CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |