SCHEMBL8069602

SCHEMBL8069602

CC[C@H]1CN1Cc1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.49
BRD4 O60885 1/20 0.48
SIGMAR1 Q99720 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23802899 1.00 MAPT (0.49) MAPTBRD4SIGMAR1
SCHEMBL7261255 1.00 MAPT (0.49) MAPTBRD4SIGMAR1
SCHEMBL7260236 1.00 MAPT (0.49) MAPTBRD4SIGMAR1
SCHEMBL7260230 1.00 MAPT (0.49) MAPTBRD4SIGMAR1
SCHEMBL7261260 1.00 MAPT (0.49) MAPTBRD4SIGMAR1
SCHEMBL11219257 0.94 MAPT (0.45) MAPTBRD4SIGMAR1
SCHEMBL23040074 0.86 BRD4 (0.48) MAPTBRD4
SCHEMBL26926615 0.86 BRD4 (0.48) MAPTBRD4
SCHEMBL7955744 0.84 MAPT (0.50) MAPTBRD4
SCHEMBL5562968 0.83 SIGMAR1 (0.61) SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118043042-A Conjugate comprising a covalent binding agent for targeting intracellular KRAS G12C proteins 瑞择生物公司 2024-05-14 CN disclosed
WO-2023014979-A9 CONJUGATES COMPRISING COVALENT BINDERS FOR TARGETING INTRACELLULAR KRAS G12C PROTEINS RAYZEBIO, INC. (US) 2023-04-27 WO disclosed
WO-2023014979-A9 CONJUGATES COMPRISING COVALENT BINDERS FOR TARGETING INTRACELLULAR KRAS G12C PROTEINS RAYZEBIO, INC. (US) 2023-04-27 WO disclosed
WO-2023014979-A1 CONJUGATES COMPRISING COVALENT BINDERS FOR TARGETING INTRACELLULAR KRAS G12C PROTEINS RAYZEBIO, INC. (US) 2023-02-09 WO disclosed
WO-2023014979-A1 CONJUGATES COMPRISING COVALENT BINDERS FOR TARGETING INTRACELLULAR KRAS G12C PROTEINS RAYZEBIO, INC. (US) 2023-02-09 WO disclosed
EP-0883610-B1 PROCESS FOR PREPARING 1,4,7,10-TETRAAZACYCLODODECANE AND ITS DERIVATIVES SCHERING AG (DE) 2000-07-12 EP disclosed
EP-0883610-A1 PROCESS FOR PREPARING 1,4,7,10-TETRAAZACYCLODODECANE AND ITS DERIVATIVES SCHERING AKTIENGESELLSCHAFT (DE) 1998-12-16 EP disclosed
US-5744616-A CYCLOTETRAMERIZATION OF A BENZYLAZIRIDINE DERIVATIVE SCHERING AKTIENGESELLSCHAFT (DE) 1998-04-28 US disclosed
WO-1997031905-A1 PROCESS FOR PREPARING 1,4,7,10-TETRAAZACYCLODODECANE AND ITS DERIVATIVES SCHERING AKTIENGESELLSCHAFT (DE) 1997-09-04 WO disclosed