Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 18/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | CYP2J2 | P51589 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4535274 | 0.87 | EPHX2 (0.67) | EPHX2CYP2C9CYP2J2CYP2C19 | |
| SCHEMBL4542284 | 0.82 | EPHX2 (0.58) | EPHX2CYP2C9CYP2J2CYP2C19 | |
| SCHEMBL4531267 | 0.78 | EPHX2 (0.66) | EPHX2CYP2C9CYP2J2 | |
| SCHEMBL4539590 | 0.78 | EPHX2 (0.68) | EPHX2CYP2C9CYP2J2CYP2C19 | |
| SCHEMBL4542529 | 0.76 | EPHX2 (0.59) | EPHX2CYP2C9CYP2J2CYP2C19 | |
| SCHEMBL13873320 | 0.75 | EPHX2 (1.00) | EPHX2CYP2C9CYP2J2CYP2C19 | |
| SCHEMBL4535373 | 0.73 | EPHX2 (0.46) | EPHX2 | |
| SCHEMBL4542310 | 0.72 | EPHX2 (0.57) | EPHX2CYP2C9CYP2J2 | |
| SCHEMBL4537421 | 0.72 | EPHX2 (0.59) | EPHX2CYP2C9CYP2J2CYP2C19 | |
| SCHEMBL8060217 | 0.72 | EPHX2 (0.56) | EPHX2CYP2C9CYP2J2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |