Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 16/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 8/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4542310 | 0.95 | EPHX2 (0.57) | EPHX2ALDH1A1LMNAGAAHTT | |
| SCHEMBL4535381 | 0.89 | EPHX2 (0.58) | EPHX2EPHX1CYP2C9CYP2J2 | |
| SCHEMBL4535274 | 0.89 | EPHX2 (0.67) | EPHX2ALDH1A1LMNAGAAHTT | |
| SCHEMBL4539590 | 0.88 | EPHX2 (0.68) | EPHX2CYP2C9CYP2J2 | |
| SCHEMBL4537166 | 0.87 | USP30 (0.50) | EPHX2SMN1; SMN2EPHX1 | |
| SCHEMBL4537295 | 0.84 | ALDH1A1 (0.49) | EPHX2ALDH1A1LMNAGAAHTT | |
| SCHEMBL4542284 | 0.83 | EPHX2 (0.58) | EPHX2CYP2C9CYP2J2 | |
| SCHEMBL4537421 | 0.82 | EPHX2 (0.59) | EPHX2CYP2C9CYP2J2 | |
| SCHEMBL4533493 | 0.81 | ALDH1A1 (0.48) | EPHX2ALDH1A1LMNAGAAHTT | |
| SCHEMBL8066384 | 0.81 | USP30 (0.54) | EPHX2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |