Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 4/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.40 |
| ▸ | CTSA | P10619 | 4/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3465815 | 0.90 | PDE4B (0.63) | PDE4BPDE4DCHRM3CTSAMRGPRX4 | |
| SCHEMBL13578425 | 0.87 | PDE4B (0.52) | PDE4BPDE4DSLC6A9TAAR1DHODH | |
| SCHEMBL29406552 | 0.82 | PDE4D (0.61) | PDE4BPDE4DCHRM3CTSAMRGPRX4 | |
| SCHEMBL13578468 | 0.82 | PDE4D (0.61) | PDE4BPDE4DCHRM3CTSAMRGPRX4 | |
| SCHEMBL3794103 | 0.79 | PDE4D (0.52) | PDE4BPDE4DCHRM3CTSAMRGPRX4 | |
| SCHEMBL3790138 | 0.76 | PDE4B (0.63) | PDE4BPDE4DSLC6A9TAAR1 | |
| SCHEMBL8063138 | 0.76 | PDE4B (0.63) | PDE4BPDE4DSLC6A9TAAR1 | |
| SCHEMBL3796788 | 0.74 | PDE4B (0.54) | PDE4BPDE4DSLC6A9DHODH | |
| SCHEMBL31297174 | 0.73 | PDE4B (0.59) | PDE4BPDE4DTAAR1DHODH | |
| SCHEMBL15195923 | 0.71 | PDE4B (0.53) | PDE4BPDE4DCTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |