Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 7/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.41 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | RORB | Q92753 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28709947 | 0.87 | PDE4B (0.62) | PDE4BPDE4DNPC1MAPTTSHR | |
| SCHEMBL13578468 | 0.85 | PDE4D (0.61) | PDE4BPDE4DNPC1MAPTTSHR | |
| SCHEMBL29406552 | 0.85 | PDE4D (0.61) | PDE4BPDE4DNPC1MAPTTSHR | |
| SCHEMBL3466479 | 0.85 | PDE4B (0.60) | PDE4BPDE4DNPC1MAPTTSHR | |
| SCHEMBL5099550 | 0.82 | PDE4D (0.56) | PDE4BPDE4DNPC1MAPTTSHR | |
| SCHEMBL8063138 | 0.82 | PDE4B (0.63) | PDE4BPDE4DTAAR1 | |
| Hydrochloric Acid SCHEMBL3793938 | 0.81 | PDE4D (0.69) | PDE4BPDE4DTAAR1PTGES2MAPK10 | |
| SCHEMBL3788487 | 0.81 | PDE4D (0.69) | PDE4BPDE4DTAAR1PTGES2MAPK10 | |
| SCHEMBL17633592 | 0.81 | PDE4D (0.66) | PDE4BPDE4DSMN1; SMN2MAPK10HTR7 | |
| SCHEMBL8065449 | 0.81 | PDE4D (0.63) | PDE4BPDE4DTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |