SCHEMBL8069856

SCHEMBL8069856

CC(=O)OC(C(=O)O)c1ccc(C)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.51
CYP3A4 P08684 2/20 0.51
LMNA P02545 3/20 0.44
HSD17B10 Q99714 1/20 0.43
KEAP1 Q14145 1/20 0.42
NFE2L2 Q16236 1/20 0.42
TSHR P16473 2/20 0.41
MAPK1 P28482 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
TDP1 Q9NUW8 1/20 0.39
RAB9A P51151 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
PKM P14618 1/20 0.39
STAT3 P40763 1/20 0.38
CASP3 P42574 1/20 0.37
CASP2 P42575 1/20 0.37
CASP7 P55210 1/20 0.37
CASP6 P55212 1/20 0.37
CASP8 Q14790 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8068274 0.85 CYP3A4 (0.51) ALDH1A1CYP3A4LMNAHSD17B10TSHR
SCHEMBL628737 0.84 ALDH1A1 (0.70) ALDH1A1CYP3A4LMNAHSD17B10TSHR
SCHEMBL1286155 0.84 ALDH1A1 (0.70) ALDH1A1CYP3A4LMNAHSD17B10TSHR
SCHEMBL493954 0.84 ALDH1A1 (0.70) ALDH1A1CYP3A4LMNAHSD17B10TSHR
SCHEMBL266721 0.83 ALDH1A1 (0.50) ALDH1A1CYP3A4LMNAHSD17B10TSHR
SCHEMBL8032589 0.83 ALDH1A1 (0.50) ALDH1A1CYP3A4LMNAHSD17B10TSHR
SCHEMBL8069812 0.83 PPARG (0.50) ALDH1A1CYP3A4LMNAHSD17B10TSHR
SCHEMBL3091554 0.83 CYP1A2 (0.52) ALDH1A1CYP3A4HSD17B10TSHRSMN1; SMN2
SCHEMBL266723 0.83 ALDH1A1 (0.50) ALDH1A1CYP3A4LMNAHSD17B10TSHR
SCHEMBL266722 0.83 ALDH1A1 (0.50) ALDH1A1CYP3A4LMNAHSD17B10TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6054479-A FOR FOOD, COSMETICS, DRUGS; ADDING ARYL ACETOXYACETIC ACID TRISTRATA, INC. (A DELAWARE CORPORATION) (US) 2000-04-25 US disclosed
US-6046238-A TOPICALLY APPLYING TO AN AFFECTED AREA OF SKIN AN EFFECTIVE AMOUNT OF ARYL 2-ACETOXYETHANOIC ACID, EFFECTIVE TO REMOVE OR PREVENT THE SPREAD OF ACNE VULGARIS TRISTRATA, INC. (US) 2000-04-04 US disclosed
US-5958975-A REVERSING OR PREVENTING TACHYPHYLAXIS OF PSORIASIS TO A CORTICOSTEROID; APPLYING TO PSORIATIC SKIN A CORTICOSTEROID AND AN ARYL 2-ACETOXY-ETHANOIC ACID; COSMETICS; FOODS TRISTRATA, INC. (US) 1999-09-28 US disclosed
US-5874071-A USING AN ARYL 2-ACETOXYETHANOIC ACID; DEODERANTS; ANTIPRESPIRANTS; PREVENTION OF ODORS ASSOCIATED WITH FOOT, SCALP, SKIN, NAILS AND FOLLICULR INFECTIONS; PROPIONIBACTERIUM ACNES; FOODS; COSMETICS; DRUGS TRISTRATA, INC. (US) 1999-02-23 US disclosed
US-5807890-A USING ARYL 2-ACETOXYETHANOIC ACID TRISTRATA, INC. (US) 1998-09-15 US disclosed
US-5641475-A INCLUDES ARYL 2-ACETOXYETHANOIC ACID AS SYNERGIST OR AMPLIFIER TRISTRATA, INC. (US) 1997-06-24 US disclosed
EP-0273017-B1 N-ALKYL DERIVATIVES OF 2-AMINO-6,7-DIMETHOXY TETRALINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS HAVING ANTIHYPERTENSIVE ACTIVITY CONTAINING SAME SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. (IT) 1992-09-16 EP disclosed
US-5047433-A N-alkyl derivatives of 2-amino-6,7-dimethoxy tetraline and pharmaceutical compositions having antihypertensive activity containing same SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) 1991-09-10 US disclosed
EP-0273017-A2 N-alkyl derivatives of 2-amino-6,7-dimethoxy tetraline, process for their preparation and pharmaceutical compositions having antihypertensive activity containing same SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. (IT) 1988-06-29 EP disclosed