Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 19/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 15/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 14/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8072173 | 0.91 | PIK3CD (0.51) | PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL14898410 | 0.89 | PIK3CA (0.49) | PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL3656793 | 0.87 | PIK3CA (0.63) | PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL13059920 | 0.85 | PIK3CA (0.46) | PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL8071369 | 0.79 | PIK3CA (0.72) | PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL14898482 | 0.79 | PIK3CD (0.52) | PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL3656010 | 0.77 | PIK3CD (0.66) | PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL13059918 | 0.76 | PIK3CD (0.50) | PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL15386239 | 0.74 | PIK3CA (0.47) | PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL8067193 | 0.73 | PIK3CA (0.52) | PIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100292468-A1 | PROCESS FOR MAKING THIENOPYRIMIDINE COMPOUNDS | GENETECH, INC | 2010-11-18 | — | — | US | disclosed |
| WO-2009055730-A1 | PROCESS FOR MAKING THIENOPYRIMIDINE COMPOUNDS | GENENTECH, INC. (US) | 2009-04-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292468-A1 | PROCESS FOR MAKING THIENOPYRIMIDINE COMPOUNDS | PIK3CA, PIK3CD, PIK3CB | PIK3CA 1/4885PIK3CB 3/4885PIK3CD 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.