Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 15/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD1 | P21728 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8073394 | 0.96 | PARP1 (0.47) | PARP1KDM4EALDH1A1MAPTDRD2 | |
| SCHEMBL8059345 | 0.89 | PARP1 (0.46) | PARP1KDM4EMAPT | |
| SCHEMBL8070000 | 0.79 | PARP1 (0.50) | PARP1KDM4EALDH1A1MAPTDRD2 | |
| SCHEMBL8068502 | 0.77 | PARP1 (0.37) | PARP1KDM4EALDH1A1MAPT | |
| SCHEMBL8069953 | 0.76 | MCL1 (0.40) | PARP1KDM4EALDH1A1MAPT | |
| SCHEMBL8073391 | 0.76 | PARP1 (0.48) | PARP1KDM4EALDH1A1MAPTDRD2 | |
| SCHEMBL8069960 | 0.76 | BRD3 (0.38) | PARP1KDM4EMAPTDRD2 | |
| SCHEMBL8068333 | 0.74 | PARP1 (0.37) | PARP1KDM4EALDH1A1MAPT | |
| SCHEMBL8070432 | 0.74 | PARP1 (0.37) | PARP1KDM4EALDH1A1MAPTDRD2 | |
| SCHEMBL8059445 | 0.74 | PARP1 (0.37) | PARP1KDM4EALDH1A1MAPTDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0803501-B1 | Substituted guanidine derivatives and their use as Na+/H+ exchange inhibitors | SUMITOMO PHARMA (JP) | 2000-07-05 | — | — | EP | disclosed |
| EP-0803501-A1 | Substituted guanidine derivatives and their use as Na+/H+ exchange inhibitors | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1997-10-29 | — | — | EP | disclosed |