Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 2/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.42 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27343744 | 0.81 | EED (0.53) | DDB1CRBNSLC6A4ALDH1A1GAA | |
| SCHEMBL837901 | 0.80 | DDB1 (0.60) | DDB1CRBNALDH1A1POLBKMT2A | |
| SCHEMBL30996579 | 0.77 | TSHR (0.48) | CRBNALDH1A1GAAPOLBKMT2A | |
| SCHEMBL4961020 | 0.77 | ALDH1A1 (0.50) | DDB1CRBNSMN1; SMN2PDE4DALDH1A1 | |
| SCHEMBL28104271 | 0.75 | DAO (0.42) | DDB1CRBNNISCHHTTALDH1A1 | |
| SCHEMBL28260107 | 0.74 | KMT2A (0.43) | DDB1CRBNSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL27429818 | 0.74 | GSK3B (0.49) | DDB1CRBNPDE4DALDH1A1 | |
| SCHEMBL22237415 | 0.73 | SMN1; SMN2 (0.51) | SMN1; SMN2SLC6A2SLC6A4HTTALDH1A1 | |
| SCHEMBL13675547 | 0.73 | TAAR1 (0.38) | DDB1CRBNSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL8186635 | 0.72 | ESR1 (0.48) | DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6066666-A | OPTIONALLY N-SUBSTITUTED 3-MONO- AND DI-SUBSTITUTED 2-PYRROLIDINONES AND THIOLACTAM ANALOGS; TREAT SEIZURES, ANXIETY, AND ENHANCING 4-AMINOBUTYRIC ACID (GABA)-INDUCED CHLORIDE CURRENTS AT GABA RECEPTOR/IONOPHORE COMPLEX | WASHINGTON UNIVERSITY (US) | 2000-05-23 | — | — | US | claimed |