SCHEMBL8071108

SCHEMBL8071108

COCC1CCCN1c1cc2nc([S+]([O-])Cc3nccc(OC)c3C)[nH]c2cc1F

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAP4K1 Q92918 1/20 0.39
ATP4A P20648 7/20 0.38
ATP4B P51164 7/20 0.38
ATP1A1 P05023 6/20 0.38
ATP1B1 P05026 6/20 0.38
ATP1A3 P13637 6/20 0.38
ATP1B2 P14415 6/20 0.38
ATP1A2 P50993 6/20 0.38
ATP1B3 P54709 6/20 0.38
FXYD2 P54710 6/20 0.38
ATP1A4 Q13733 6/20 0.38
ROCK2 O75116 1/20 0.36
ROCK1 Q13464 1/20 0.36
CDC42BPB Q9Y5S2 1/20 0.36
PIM1 P11309 2/20 0.32
PIM2 Q9P1W9 2/20 0.32
PIM3 Q86V86 1/20 0.32
ADORA2A P29274 3/20 0.31
PDE10A Q9Y233 1/20 0.31
CRHR1 P34998 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8073957 0.85 ATP4A (0.42) ATP4AATP4BATP1A1ATP1B1ATP1A3
SCHEMBL8059927 0.84 ATP4A (0.42) ATP4AATP4BATP1A1ATP1B1ATP1A3
SCHEMBL8061865 0.84 ATP4A (0.42) ATP4AATP4BATP1A1ATP1B1ATP1A3
SCHEMBL8059824 0.83 OPRL1 (0.44) MAP4K1ATP4AATP4BATP1A1ATP1B1
SCHEMBL8071077 0.83 ATP4A (0.40) ATP4AATP4BATP1A1ATP1B1ATP1A3
SCHEMBL8977409 0.81 ATP4A (0.43) ATP4AATP4BATP1A1ATP1B1ATP1A3
SCHEMBL10335419 0.81 ATP4A (0.48) ATP4AATP4BATP1A1ATP1B1ATP1A3
SCHEMBL8977408 0.81 ATP4A (0.43) ATP4AATP4BATP1A1ATP1B1ATP1A3
SCHEMBL8074093 0.80 ATP4A (0.44) ATP4AATP4BATP1A1ATP1B1ATP1A3
SCHEMBL8977272 0.80 ATP4A (0.42) ATP4AATP4BATP1A1ATP1B1ATP1A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6051570-A ANTIULCER AGENTS DR. REDDY'S RESEARCH FOUNDATION (IN) 2000-04-18 US disclosed