Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RYR2 | Q92736 | 5/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.52 |
| ▸ | DRD1 | P21728 | 6/20 | 0.50 |
| ▸ | DRD5 | P21918 | 5/20 | 0.50 |
| ▸ | DRD2 | P14416 | 4/20 | 0.50 |
| ▸ | DRD4 | P21917 | 4/20 | 0.50 |
| ▸ | DRD3 | P35462 | 4/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.50 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL807139 | 0.89 | RYR2 (0.62) | RYR2HSD17B10ESR1ESR2DRD1 | |
| SCHEMBL5446558 | 0.81 | ESR1 (0.59) | RYR2HSD17B10ESR1ESR2DRD1 | |
| SCHEMBL5446563 | 0.79 | DRD1 (0.54) | RYR2HSD17B10ESR1ESR2DRD1 | |
| SCHEMBL14385483 | 0.78 | HSD17B10 (0.49) | HSD17B10ESR1ESR2DRD1DRD5 | |
| SCHEMBL8247399 | 0.78 | ESR1 (0.63) | ESR1ESR2DRD1DRD5ABHD6 | |
| SCHEMBL7847325 | 0.77 | ESR1 (0.85) | RYR2HSD17B10ESR1ESR2DRD1 | |
| SCHEMBL30677763 | 0.77 | ESR1 (0.57) | RYR2ESR1ESR2ABHD6CA1 | |
| SCHEMBL15880544 | 0.77 | ESR1 (0.57) | RYR2ESR1ESR2ABHD6CA1 | |
| SCHEMBL5123364 | 0.77 | DRD1 (0.76) | RYR2HSD17B10DRD1DRD5DRD2 | |
| SCHEMBL13580211 | 0.77 | ABHD6 (0.62) | ESR1ESR2DRD1DRD5DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037105-A1 | METHODS OF TREATING, AMELIORATING OR PREVENTING STRESS-INDUCED NEURONAL DISORDERS AND DISEASES | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2012-03-22 | — | — | WO | disclosed |
| WO-2012019071-A1 | METHODS OF PREVENTING AND TREATING SARCOPENIA | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2012-02-09 | — | — | WO | disclosed |
| WO-2012019076-A1 | COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING CARDIAC ISCHEMIA/REPERFUSION INJURY | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2012-02-09 | — | — | WO | disclosed |
| WO-2008144483-A2 | AGENTS FOR TREATING DISORDERS INVOLVING MODULATION OF RYANODINE RECEPTORS | ARMGO PHARMA, INC. (US) | 2008-11-27 | — | — | WO | disclosed |