Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 5/20 | 0.60 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.60 |
| ▸ | WHR1 | P49842 | 2/20 | 0.50 |
| ▸ | KMT5A | Q9NQR1 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | GLA | P06280 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.47 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8076777 | 0.93 | TLR9 (0.58) | TLR9TLR7WHR1KMT5AKDM4E | |
| SCHEMBL8071627 | 0.89 | TLR9 (0.53) | TLR9TLR7WHR1KMT5AKDM4E | |
| SCHEMBL8076201 | 0.85 | KDM4E (0.58) | WHR1KDM4EALDH1A1HPGDGLA | |
| SCHEMBL8075717 | 0.82 | WHR1 (0.42) | TLR9TLR7WHR1KDM4EALDH1A1 | |
| SCHEMBL2923197 | 0.81 | TLR9 (0.66) | TLR9TLR7WHR1KMT5AKDM4E | |
| SCHEMBL2918315 | 0.80 | TLR9 (0.66) | TLR9TLR7KMT5AALDH1A1ACHE | |
| SCHEMBL19385275 | 0.77 | TLR9 (0.67) | TLR9TLR7WHR1KMT5AALDH1A1 | |
| SCHEMBL29937021 | 0.77 | TLR9 (0.73) | TLR9TLR7WHR1KMT5AKDM4E | |
| SCHEMBL19385278 | 0.77 | TLR9 (0.73) | TLR9TLR7WHR1KMT5AKDM4E | |
| SCHEMBL8076773 | 0.76 | KDM4E (0.42) | TLR9TLR7WHR1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6156758-A | Antibacterial quinazoline compounds | ISIS PHARMACEUTICALS, INC. (US) | 2000-12-05 | — | — | US | disclosed |