Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.52 |
| ▸ | USP30 | Q70CQ3 | 8/20 | 0.48 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.46 |
| ▸ | RXRA | P19793 | 2/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.46 |
| ▸ | TACR1 | P25103 | 2/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.45 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2241984 | 0.90 | USP30 (0.53) | RORCUSP30NR1H2RXRANR1H3 | |
| SCHEMBL12362416 | 0.90 | USP30 (0.53) | RORCUSP30NR1H2RXRANR1H3 | |
| SCHEMBL12354146 | 0.90 | USP30 (0.53) | RORCUSP30NR1H2RXRANR1H3 | |
| SCHEMBL13975432 | 0.89 | RORC (0.62) | RORCUSP30TACR1PDE4B | |
| SCHEMBL2331698 | 0.89 | RORC (0.62) | RORCUSP30TACR1PDE4B | |
| SCHEMBL376884 | 0.89 | RORC (0.62) | RORCUSP30TACR1PDE4B | |
| SCHEMBL15730035 | 0.89 | RORC (0.62) | RORCUSP30TACR1PDE4B | |
| SCHEMBL10238398 | 0.89 | RORC (0.62) | RORCUSP30TACR1PDE4B | |
| SCHEMBL528059 | 0.89 | RORC (0.62) | RORCUSP30TACR1PDE4B | |
| SCHEMBL528139 | 0.85 | DPP4 (0.51) | RORCTACR1PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012036997-A1 | FUSED PYRAZOLE DERIVATIVES AS NOVEL ERK INHIBITORS | SCHERING CORPORATION (US) | 2012-03-22 | — | — | WO | disclosed |