Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.54 |
| ▸ | DRD3 | P35462 | 4/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | DRD5 | P21918 | 2/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5889365 | 1.00 | DRD2 (0.54) | DRD2DRD3ADRA1AMAPTNFKB1 | |
| SCHEMBL8070886 | 1.00 | DRD2 (0.54) | DRD2DRD3ADRA1AMAPTNFKB1 | |
| SCHEMBL8070887 | 1.00 | DRD2 (0.54) | DRD2DRD3ADRA1AMAPTNFKB1 | |
| SCHEMBL5889364 | 1.00 | DRD2 (0.54) | DRD2DRD3ADRA1AMAPTNFKB1 | |
| Hydrochloric Acid SCHEMBL5889333 | 0.98 | DRD2 (0.53) | DRD2DRD3ADRA1AMAPTNFKB1 | |
| Hydrochloric Acid SCHEMBL5889375 | 0.98 | DRD2 (0.53) | DRD2DRD3ADRA1AMAPTNFKB1 | |
| Hydrochloric Acid SCHEMBL8070795 | 0.98 | DRD2 (0.53) | DRD2DRD3ADRA1AMAPTNFKB1 | |
| Hydrochloric Acid SCHEMBL5889349 | 0.98 | DRD2 (0.53) | DRD2DRD3ADRA1AMAPTNFKB1 | |
| Hydrochloric Acid SCHEMBL5889345 | 0.98 | DRD2 (0.53) | DRD2DRD3ADRA1AMAPTNFKB1 | |
| SCHEMBL7339771 | 0.88 | DRD2 (0.62) | DRD2DRD3ADRA1AMAPTNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0730861-B1 | Use of 6,7-substituted-2-aminotetralines for preparing pharmaceutical compositions useful for the treatment of septic shock, and antipyretic and antiinflammatory pharmaceutical compositions | SIGMA TAU IND FARMACEUTI (IT) | 2000-08-02 | — | — | EP | claimed |
| US-5591777-A | Use of 6,7-substituted-2-aminotetralines for preparing pharmaceutical compositions useful for the treatment of septic shock, and antipyretic and antiinflammatory pharmaceutical compositions | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 1997-01-07 | — | — | US | claimed |
| EP-0730861-A1 | Use of 6,7-substituted-2-aminotetralines for preparing pharmaceutical compositions useful for the treatment of septic shock, and antipyretic and antiinflammatory pharmaceutical compositions | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1996-09-11 | — | — | EP | claimed |
| EP-0466662-B1 | 6,7-disubstituted-2-aminotetralines active as immunomodulators and pharmaceutical compositions containing same | SIGMA TAU IND FARMACEUTI (IT) | 1995-10-18 | — | — | EP | claimed |
| EP-0466662-A2 | 6,7-disubstituted-2-aminotetralines active as immunomodulators and pharmaceutical compositions containing same | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1992-01-15 | — | — | EP | claimed |
| EP-0730861-B1 | Use of 6,7-substituted-2-aminotetralines for preparing pharmaceutical compositions useful for the treatment of septic shock, and antipyretic and antiinflammatory pharmaceutical compositions | SIGMA TAU IND FARMACEUTI (IT) | 2000-08-02 | — | — | EP | disclosed |
| US-5962525-A | IMMUNOMODULATOR | SIGMA-TAU (IT) | 1999-10-05 | — | — | US | disclosed |
| US-5637614-A | IMMUNOMODULATOR | SIGMA TAU (IT) | 1997-06-10 | — | — | US | disclosed |
| US-5591777-A | Use of 6,7-substituted-2-aminotetralines for preparing pharmaceutical compositions useful for the treatment of septic shock, and antipyretic and antiinflammatory pharmaceutical compositions | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 1997-01-07 | — | — | US | disclosed |
| US-5591777-A | Use of 6,7-substituted-2-aminotetralines for preparing pharmaceutical compositions useful for the treatment of septic shock, and antipyretic and antiinflammatory pharmaceutical compositions | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 1997-01-07 | — | — | US | disclosed |
| EP-0730861-A1 | Use of 6,7-substituted-2-aminotetralines for preparing pharmaceutical compositions useful for the treatment of septic shock, and antipyretic and antiinflammatory pharmaceutical compositions | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1996-09-11 | — | — | EP | disclosed |
| EP-0730861-A1 | Use of 6,7-substituted-2-aminotetralines for preparing pharmaceutical compositions useful for the treatment of septic shock, and antipyretic and antiinflammatory pharmaceutical compositions | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1996-09-11 | — | — | EP | disclosed |
| EP-0466662-B1 | 6,7-disubstituted-2-aminotetralines active as immunomodulators and pharmaceutical compositions containing same | SIGMA TAU IND FARMACEUTI (IT) | 1995-10-18 | — | — | EP | disclosed |
| EP-0466662-A2 | 6,7-disubstituted-2-aminotetralines active as immunomodulators and pharmaceutical compositions containing same | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1992-01-15 | — | — | EP | disclosed |