Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | CA12 | O43570 | 2/20 | 0.56 |
| ▸ | CA1 | P00915 | 2/20 | 0.56 |
| ▸ | CA2 | P00918 | 2/20 | 0.56 |
| ▸ | CA7 | P43166 | 2/20 | 0.56 |
| ▸ | CA9 | Q16790 | 2/20 | 0.56 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.56 |
| ▸ | CA4 | P22748 | 1/20 | 0.56 |
| ▸ | CA6 | P23280 | 1/20 | 0.56 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | CASP9 | P55211 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salicylic Acid SCHEMBL27819454 | 0.83 | ALDH1A1 (0.64) | HPGDALDH1A1KDM4ECA12CA1 | |
| Ethyl Salicylate SCHEMBL27909090 | 0.82 | TSHR (0.67) | HPGDALDH1A1KDM4ECA12CA1 | |
| Toluene SCHEMBL11851365 | 0.80 | MEN1 (0.49) | ALDH1A1SMN1; SMN2TSHRMEN1KMT2A | |
| Salicylic Acid SCHEMBL8080443 | 0.79 | ALDH1A1 (0.75) | HPGDALDH1A1KDM4ECA12CA1 | |
| Salicylic Acid SCHEMBL1829341 | 0.79 | ALDH1A1 (0.82) | HPGDALDH1A1KDM4ECA12CA1 | |
| Biphenyl SCHEMBL10591521 | 0.78 | SMN1; SMN2 (0.48) | HPGDALDH1A1KDM4ESMN1; SMN2TSHR | |
| Salicylic Acid SCHEMBL25288775 | 0.77 | ALDH1A1 (0.78) | HPGDALDH1A1KDM4ECA12CA1 | |
| Salicylic Acid SCHEMBL31332109 | 0.77 | ALDH1A1 (0.78) | HPGDALDH1A1KDM4ECA12CA1 | |
| Salicylic Acid SCHEMBL1003308 | 0.77 | ALDH1A1 (0.78) | HPGDALDH1A1KDM4ECA12CA1 | |
| Salicylic Acid SCHEMBL4653438 | 0.77 | KDM4E (0.64) | HPGDALDH1A1KDM4ECA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046020-A | ANTI-CAPSULE AGENT SELECTED FROM THE GROUP CONSISTING OF THIOGLYCOLATE, THIOGLYCOLATE SALTS, AND THIOGLYCOLATE ESTERS | BIOLOG, INC. (US) | 2000-04-04 | — | — | US | disclosed |