Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2241808 | 0.82 | APP (0.48) | APPMAPTKCNN4CYP1A2CYP2C9 | |
| SCHEMBL523695 | 0.78 | MAPT (0.51) | APPMAPTKCNN4NPC1RAB9A | |
| SCHEMBL20945461 | 0.75 | NR1H2 (0.58) | MAPTNR1H2 | |
| SCHEMBL29212977 | 0.75 | MAPT (0.41) | APPMAPTKCNN4NPC1RAB9A | |
| SCHEMBL28592261 | 0.75 | MAPT (0.49) | APPMAPTCYP3A4NR1H2NPSR1 | |
| SCHEMBL487465 | 0.74 | MAPT (0.56) | APPMAPTNPC1RAB9ACYP1A2 | |
| SCHEMBL11573256 | 0.74 | CYP1A2 (0.37) | KCNN4CYP1A2CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL29211079 | 0.74 | CYP1A2 (0.41) | MAPTKCNN4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8467691 | 0.74 | MAPT (0.44) | APPMAPTKCNN4CYP1A2CYP2C9 | |
| SCHEMBL28604985 | 0.74 | CYP2D6 (0.50) | APPMAPTCYP1A2CYP2C19CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042311-A1 | PHOTOCHROMIC 6-ARYL SUBSTITUTED 3H-NAPHTHO 2,1-b]PYRANS | TRANSITIONS OPTICAL, INC. (US) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999031082-A1 | PHOTOCHROMIC 6-ARYL SUBSTITUTED 3H-NAPHTHO[2,1-b]PYRANS | TRANSITIONS OPTICAL, INC. (US) | 1999-06-24 | — | — | WO | disclosed |