Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8073787 | 1.00 | OPRL1 (0.55) | OPRL1MEN1KMT2ASLC6A2SLC6A4 | |
| SCHEMBL6983607 | 0.88 | OPRL1 (0.58) | OPRL1MEN1KMT2AOPRM1OPRD1 | |
| SCHEMBL6983605 | 0.88 | OPRL1 (0.58) | OPRL1MEN1KMT2AOPRM1OPRD1 | |
| SCHEMBL9366136 | 0.82 | SLC6A4 (0.62) | OPRL1SLC6A2SLC6A4OPRM1OPRD1 | |
| SCHEMBL8507420 | 0.77 | OPRL1 (0.63) | OPRL1SLC6A2SLC6A4CYP1A2CYP3A4 | |
| SCHEMBL3583059 | 0.77 | OPRL1 (0.63) | OPRL1SLC6A2SLC6A4CYP1A2CYP3A4 | |
| SCHEMBL1205831 | 0.77 | OPRL1 (0.63) | OPRL1SLC6A2SLC6A4CYP1A2CYP3A4 | |
| SCHEMBL14035499 | 0.76 | SLC6A4 (0.68) | OPRL1MEN1KMT2ASLC6A2SLC6A4 | |
| SCHEMBL5139722 | 0.76 | SLC6A4 (0.68) | OPRL1MEN1KMT2ASLC6A2SLC6A4 | |
| SCHEMBL13039159 | 0.75 | CYP1A2 (0.66) | OPRL1MEN1KMT2ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0789021-B1 | Hydroxamic acid compounds as opioid kappa receptor agonists | PFIZER (US) | 2000-10-11 | — | — | EP | disclosed |
| US-5837717-A | ANALGESICS, ANTIINFLAMMATORY AGENTS, ANTITUSSIVE AGENTS, DIURETICS, NEUROPROTECTIVE AGENTS; TREATING BOWEL DISEASE SUCH AS ABDOMINAL PAIN | PFIZER INC. (US) | 1998-11-17 | — | — | US | disclosed |
| EP-0789021-A1 | Hydroxamic acid compounds as opioid kappa receptor agonists | PFIZER INC. (US) | 1997-08-13 | — | — | EP | disclosed |