Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 14/20 | 0.62 |
| ▸ | SLC6A2 | P23975 | 9/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.55 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 2/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8658938 | 0.84 | MAOA (0.47) | SLC6A4SLC6A2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8073787 | 0.82 | OPRL1 (0.55) | SLC6A4SLC6A2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8073783 | 0.82 | OPRL1 (0.55) | SLC6A4SLC6A2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9365807 | 0.80 | SLC6A4 (0.40) | SLC6A4SLC6A2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9366741 | 0.78 | CYP1A2 (0.96) | SLC6A4SLC6A2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6171525 | 0.77 | SLC6A4 (1.00) | SLC6A4SLC6A2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3715253 | 0.76 | CYP1A2 (1.00) | SLC6A4SLC6A2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9366351 | 0.73 | CYP2D6 (0.70) | SLC6A4SLC6A2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8445058 | 0.73 | CYP2D6 (0.62) | CYP1A2CYP3A4CYP2D6CYP2C19OPRM1 | |
| SCHEMBL14722649 | 0.72 | CYP1A2 (0.68) | SLC6A4SLC6A2CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0346791-B1 | 1,2-diarylethylamines for treatment of neurotoxic injury | SEARLE & CO (US) | 1994-04-06 | — | — | EP | claimed |
| EP-0346791-A1 | 1,2-diarylethylamines for treatment of neurotoxic injury | G.D. Searle & Co. (US) | 1989-12-20 | — | — | EP | claimed |
| EP-0346791-B1 | 1,2-diarylethylamines for treatment of neurotoxic injury | SEARLE & CO (US) | 1994-04-06 | — | — | EP | disclosed |
| EP-0346791-A1 | 1,2-diarylethylamines for treatment of neurotoxic injury | G.D. Searle & Co. (US) | 1989-12-20 | — | — | EP | disclosed |