Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.64 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.64 |
| ▸ | CA1 | P00915 | 3/20 | 0.61 |
| ▸ | CA2 | P00918 | 3/20 | 0.61 |
| ▸ | ACHE | P22303 | 3/20 | 0.61 |
| ▸ | DRD2 | P14416 | 9/20 | 0.59 |
| ▸ | DRD3 | P35462 | 7/20 | 0.59 |
| ▸ | DRD4 | P21917 | 5/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.55 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6819517 | 1.00 | MTNR1A (0.64) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL5835471 | 0.90 | MTNR1A (0.64) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL8066344 | 0.90 | MTNR1A (0.64) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL8080874 | 0.87 | MTNR1A (0.61) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL8605995 | 0.87 | MTNR1A (0.61) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL7778584 | 0.87 | MTNR1A (0.61) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL8158536 | 0.85 | MTNR1A (0.49) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL20096622 | 0.83 | CYP1A2 (0.46) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL7924693 | 0.83 | CYP1A2 (0.46) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL10983820 | 0.82 | CYP1A2 (0.61) | MTNR1AMTNR1BCA1CA2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0683236-B1 | Enzymatic process for the preparation of optical active tetralin-derivatives | SANOFI SYNTHELABO (FR) | 2000-08-09 | — | — | EP | claimed |
| EP-0683236-B1 | Enzymatic process for the preparation of optical active tetralin-derivatives | SANOFI SYNTHELABO (FR) | 2000-08-09 | — | — | EP | disclosed |
| US-5719308-A | Enzymatic process for the preparation of optically active tetralin derivatives | SANOFI (FR) | 1998-02-17 | — | — | US | disclosed |
| US-5573949-A | Enzymatic process for the preparation of optically active Tetrahydro-2-naphthoic acids | SANOFI (FR) | 1996-11-12 | — | — | US | disclosed |
| EP-0683236-A1 | Enzymatic process for the preparation of optical active tetralin-derivatives | SANOFI (FR) | 1995-11-22 | — | — | EP | disclosed |