Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.63 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.63 |
| ▸ | CA1 | P00915 | 4/20 | 0.59 |
| ▸ | CA2 | P00918 | 4/20 | 0.59 |
| ▸ | ACHE | P22303 | 4/20 | 0.59 |
| ▸ | DRD2 | P14416 | 5/20 | 0.57 |
| ▸ | DRD3 | P35462 | 5/20 | 0.57 |
| ▸ | DRD4 | P21917 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 2/20 | 0.46 |
| ▸ | NQO2 | P16083 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8606735 | 1.00 | MTNR1A (0.63) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL545767 | 1.00 | MTNR1A (0.63) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL8076218 | 0.94 | CA1 (0.59) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL8603697 | 0.94 | CA1 (0.59) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL8066286 | 0.94 | CA1 (0.59) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL388601 | 0.88 | MTNR1A (0.54) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL345882 | 0.87 | MTNR1A (0.60) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL8603880 | 0.87 | MTNR1A (0.60) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL345881 | 0.87 | MTNR1A (0.60) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL10197905 | 0.86 | MTNR1A (0.48) | MTNR1AMTNR1BCA1CA2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0683236-B1 | Enzymatic process for the preparation of optical active tetralin-derivatives | SANOFI SYNTHELABO (FR) | 2000-08-09 | — | — | EP | claimed |
| US-5719308-A | Enzymatic process for the preparation of optically active tetralin derivatives | SANOFI (FR) | 1998-02-17 | — | — | US | claimed |
| EP-0683236-B1 | Enzymatic process for the preparation of optical active tetralin-derivatives | SANOFI SYNTHELABO (FR) | 2000-08-09 | — | — | EP | disclosed |
| US-5719308-A | Enzymatic process for the preparation of optically active tetralin derivatives | SANOFI (FR) | 1998-02-17 | — | — | US | disclosed |
| US-5573949-A | Enzymatic process for the preparation of optically active Tetrahydro-2-naphthoic acids | SANOFI (FR) | 1996-11-12 | — | — | US | disclosed |
| EP-0683236-A1 | Enzymatic process for the preparation of optical active tetralin-derivatives | SANOFI (FR) | 1995-11-22 | — | — | EP | disclosed |
| EP-0678579-A1 | Enzymatic process for the preparation of optical active tetralin-derivatives | MIDY S.p.A. (IT) | 1995-10-25 | — | — | EP | disclosed |