Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK3 | P27361 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15065226 | 0.82 | MAPK1 (0.43) | MAPK1 | |
| SCHEMBL15064740 | 0.81 | MAPK1 (0.43) | MAPK3MAPK1MAP2K1 | |
| SCHEMBL806916 | 0.73 | MAPK1 (0.44) | MAPK3MAPK1MAP2K1 | |
| SCHEMBL15065272 | 0.72 | MAPK1 (0.44) | MAPK3MAPK1MAP2K1 | |
| SCHEMBL807657 | 0.70 | MAPK1 (0.58) | MAPK3MAPK1MAP2K1BRD4CREBBP | |
| SCHEMBL15084407 | 0.68 | — | — | |
| SCHEMBL10210896 | 0.67 | — | — | |
| SCHEMBL807217 | 0.67 | MAPK1 (0.60) | MAPK3MAPK1MAP2K1BRD4CREBBP | |
| SCHEMBL15084396 | 0.66 | — | — | |
| SCHEMBL15065403 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012036997-A1 | FUSED PYRAZOLE DERIVATIVES AS NOVEL ERK INHIBITORS | SCHERING CORPORATION (US) | 2012-03-22 | — | — | WO | disclosed |