Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17909875 | 0.81 | NPC1 (0.43) | KMT2AKDM4EPOLBNPC1RAB9A | |
| SCHEMBL529870 | 0.80 | POLB (0.66) | KMT2AKDM4EPOLBMEN1MAOB | |
| SCHEMBL3065409 | 0.80 | GAA (0.63) | KMT2ARAB9AHTTGAATSHR | |
| SCHEMBL17909820 | 0.79 | CYP3A4 (0.44) | KMT2AKDM4EGPBAR1NOTUM | |
| SCHEMBL3053888 | 0.77 | PDK1 (0.45) | KMT2AKDM4EHTTGAATSHR | |
| SCHEMBL3062054 | 0.77 | HTT (0.45) | KMT2AKDM4EHTTGAATSHR | |
| SCHEMBL17909863 | 0.77 | DOT1L (0.42) | KMT2APOLBMEN1NPC1RAB9A | |
| SCHEMBL3044381 | 0.76 | TSHR (0.49) | KMT2ARAB9AHTTGAATSHR | |
| SCHEMBL3056502 | 0.76 | TSHR (0.49) | KMT2ARAB9AHTTGAATSHR | |
| SCHEMBL17909894 | 0.76 | PDE10A (0.42) | KMT2AMEN1GPBAR1NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6054469-A | Substituted tetrahydropyridine derivatives acting on 5-HT receptors | MERCK SHARP & DOHME LTD. (GB) | 2000-04-25 | — | — | US | disclosed |
| WO-1997018204-A1 | SUBSTITUTED TETRAHYDROPYRIDINE DERIVATIVES ACTING ON 5-HT RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 1997-05-22 | — | — | WO | disclosed |