Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 6/20 | 0.35 |
| ▸ | HTR2A | P28223 | 4/20 | 0.35 |
| ▸ | HTR2B | P41595 | 4/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15081942 | 1.00 | SLC6A2 (0.37) | SLC6A2SLC6A4SLC6A3KIF11KDM1A | |
| SCHEMBL15082019 | 1.00 | SLC6A2 (0.37) | SLC6A2SLC6A4SLC6A3KIF11KDM1A | |
| SCHEMBL807454 | 0.85 | MAOA (0.43) | SLC6A2SLC6A3KIF11KDM1AMAOA | |
| SCHEMBL17084154 | 0.85 | MAOA (0.43) | SLC6A2SLC6A3KIF11KDM1AMAOA | |
| SCHEMBL17084189 | 0.85 | MAOA (0.43) | SLC6A2SLC6A3KIF11KDM1AMAOA | |
| SCHEMBL15081932 | 0.85 | MAOA (0.43) | SLC6A2SLC6A3KIF11KDM1AMAOA | |
| SCHEMBL15084369 | 0.80 | KDM1A (0.37) | SLC6A2SLC6A4SLC6A3KDM1AMAOA | |
| SCHEMBL15082020 | 0.75 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3HRH3HSD17B2 | |
| SCHEMBL15081944 | 0.75 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3HRH3HSD17B2 | |
| SCHEMBL15081930 | 0.70 | HTR2C (0.37) | SLC6A2SLC6A4SLC6A3HTR2CHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012036997-A1 | FUSED PYRAZOLE DERIVATIVES AS NOVEL ERK INHIBITORS | SCHERING CORPORATION (US) | 2012-03-22 | — | — | WO | disclosed |