Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | RGS12 | O14924 | 1/20 | 0.37 |
| ▸ | TOP1 | P11387 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8081180 | 0.93 | NPC1 (0.46) | NPC1MAPTKDM4EMAPK1NPSR1 | |
| SCHEMBL8076775 | 0.93 | NPC1 (0.47) | NPC1MAPTKDM4EMAPK1NPSR1 | |
| SCHEMBL8001310 | 0.92 | NPC1 (0.46) | NPC1MAPTKDM4EMAPK1NPSR1 | |
| SCHEMBL8004045 | 0.90 | NPC1 (0.45) | NPC1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL8000796 | 0.90 | NPC1 (0.54) | NPC1MAPTKDM4EMAPK1NPSR1 | |
| SCHEMBL8004496 | 0.86 | NPC1 (0.52) | NPC1KDM4ENPSR1MEN1KMT2A | |
| SCHEMBL7997072 | 0.86 | NPC1 (0.49) | NPC1MAPTKDM4EMAPK1NPSR1 | |
| SCHEMBL8004788 | 0.86 | NPC1 (0.51) | NPC1MAPTKDM4EMAPK1NPSR1 | |
| SCHEMBL7989239 | 0.86 | NPC1 (0.51) | NPC1MAPTKDM4EMAPK1NPSR1 | |
| SCHEMBL7989064 | 0.86 | NPC1 (0.51) | NPC1MAPTKDM4EMAPK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0785190-B1 | Quinolinone derivative and antiallergic agent with said quinolinone derivative as the active ingredient | DAINIPPON INK & CHEMICALS (JP) | 2000-08-16 | — | — | EP | disclosed |
| US-5942521-A | Quinolinone derivative and anti-allergic agent with said quinolinone derivative as the active ingredient | DAINIPPON INK AND CHEMICALS, INC. (JP) | 1999-08-24 | — | — | US | disclosed |
| EP-0785190-A2 | Quinolinone derivative and antiallergic agent with said quinolinone derivative as the active ingredient | DAINIPPON INK AND CHEMICALS, INC. (JP) | 1997-07-23 | — | — | EP | disclosed |