Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | UBE2N | P61088 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8069930 | 0.87 | MEN1 (0.47) | MEN1KMT2APOLBPABPC1KDM4E | |
| SCHEMBL8074878 | 0.83 | KMT2A (0.41) | MEN1KMT2APOLBPABPC1KDM4E | |
| SCHEMBL8070221 | 0.82 | MEN1 (0.48) | MEN1KMT2APOLBPABPC1KDM4E | |
| SCHEMBL8068418 | 0.81 | MEN1 (0.41) | MEN1KMT2APOLBPABPC1KDM4E | |
| SCHEMBL8074847 | 0.75 | KMT2A (0.42) | MEN1KMT2APOLBPABPC1KDM4E | |
| SCHEMBL8070452 | 0.74 | KMT2A (0.40) | MEN1KMT2APOLBPABPC1KDM4E | |
| SCHEMBL8069891 | 0.72 | MEN1 (0.41) | MEN1KMT2APOLBPABPC1KDM4E | |
| SCHEMBL8073260 | 0.72 | PARP1 (0.30) | — | |
| SCHEMBL8068449 | 0.69 | ATM (0.38) | MEN1KMT2APOLBPABPC1KDM4E | |
| SCHEMBL8059452 | 0.67 | TSHR (0.47) | MEN1KMT2APOLBKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0803501-B1 | Substituted guanidine derivatives and their use as Na+/H+ exchange inhibitors | SUMITOMO PHARMA (JP) | 2000-07-05 | — | — | EP | disclosed |
| EP-0803501-A1 | Substituted guanidine derivatives and their use as Na+/H+ exchange inhibitors | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1997-10-29 | — | — | EP | disclosed |