Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | BLM | P54132 | 1/20 | 0.63 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.63 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 2/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.53 |
| ▸ | EBP | Q15125 | 1/20 | 0.53 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8088182 | 0.90 | CYP1A2 (0.57) | CYP1A2CYP3A4CYP2D6BLMPMP22 | |
| SCHEMBL6574463 | 0.85 | CYP3A4 (0.84) | CYP1A2CYP3A4CYP2D6BLMPMP22 | |
| SCHEMBL10959196 | 0.85 | SIGMAR1 (0.70) | CYP1A2CYP3A4CYP2D6BLMPMP22 | |
| SCHEMBL21623605 | 0.83 | CYP1A2 (0.69) | CYP1A2CYP3A4CYP2D6BLMPMP22 | |
| SCHEMBL29446268 | 0.82 | ATM (0.66) | CYP1A2CYP3A4CYP2D6BLMPMP22 | |
| SCHEMBL13098004 | 0.82 | ATM (0.66) | CYP1A2CYP3A4CYP2D6BLMPMP22 | |
| SCHEMBL13098012 | 0.82 | ATM (0.66) | CYP1A2CYP3A4CYP2D6BLMPMP22 | |
| SCHEMBL296593 | 0.82 | ATM (0.66) | CYP1A2CYP3A4CYP2D6BLMPMP22 | |
| Hydrochloric Acid SCHEMBL8086550 | 0.82 | BLM (0.66) | CYP1A2CYP3A4CYP2D6BLMPMP22 | |
| SCHEMBL9054003 | 0.82 | SIGMAR1 (0.47) | CYP1A2CYP3A4CYP2D6BLMPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711763-B1 | 1,4-DI(PHENYLALKYL)PIPERAZINE DERIVATIVES | SANTEN PHARMACEUTICAL CO LTD (JP) | 2000-10-18 | — | — | EP | disclosed |
| US-5736546-A | BRAIN DISORDERS; PSYCHOLOGICAL DISORDERS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1998-04-07 | — | — | US | disclosed |
| EP-0711763-A1 | NOVEL 1,4-DI(PHENYLALKYL)PIPERAZINE DERIVATIVE | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1996-05-15 | — | — | EP | disclosed |
| EP-0388081-B1 | Agent for the treatment of disorders of the cerebral neurotransmitter system | SANTEN PHARMACEUTICAL CO LTD (JP) | 1995-12-27 | — | — | EP | disclosed |
| US-5153198-A | Fluoro-diphenylethylpiperazine for treating nervous system and brain disorders | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1992-10-06 | — | — | US | disclosed |
| US-5087627-A | Administering diphenylethylpiperazine derivatives | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1992-02-11 | — | — | US | disclosed |
| EP-0388081-A2 | Agent for the treatment of disorders of the cerebral neurotransmitter system | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1990-09-19 | — | — | EP | disclosed |