Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.57 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.57 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.55 |
| ▸ | DRD2 | P14416 | 12/20 | 0.42 |
| ▸ | DRD3 | P35462 | 12/20 | 0.42 |
| ▸ | DRD4 | P21917 | 9/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4839583 | 0.90 | KCNH2 (0.64) | KCNH2SCN9ASCN5ADRD2DRD3 | |
| SCHEMBL4839594 | 0.90 | KCNH2 (0.64) | KCNH2SCN9ASCN5ADRD2DRD3 | |
| SCHEMBL8075560 | 0.82 | KCNH2 (0.61) | KCNH2SCN9ASCN5ADRD2DRD3 | |
| SCHEMBL4840083 | 0.78 | KCNH2 (0.64) | KCNH2SCN9ASCN5ADRD2DRD3 | |
| SCHEMBL4840071 | 0.78 | KCNH2 (0.64) | KCNH2SCN9ASCN5ADRD2DRD3 | |
| SCHEMBL8080619 | 0.76 | SCN9A (0.73) | KCNH2SCN9ASCN5ADRD2DRD3 | |
| SCHEMBL4840362 | 0.76 | KCNH2 (0.62) | KCNH2SCN9ASCN5ADRD2DRD3 | |
| SCHEMBL4840371 | 0.76 | KCNH2 (0.62) | KCNH2SCN9ASCN5ADRD2DRD3 | |
| SCHEMBL4842124 | 0.75 | KCNH2 (0.67) | KCNH2SCN9ASCN5ADRD2DRD3 | |
| SCHEMBL4842109 | 0.75 | KCNH2 (0.67) | KCNH2SCN9ASCN5ADRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025095-A1 | SUBSTITUTED CHROMAN DERIVATIVES | AstraZeneca AB (SE) | 2000-08-09 | — | — | EP | disclosed |
| WO-1999014212-A1 | SUBSTITUTED CHROMAN DERIVATIVES | ASTRAZENECA AB (SE) | 1999-03-25 | — | — | WO | disclosed |