Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 20/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL8075723 | 1.00 | LTB4R (0.70) | LTB4R | |
| SCHEMBL8862114 | 0.92 | LTB4R (0.83) | LTB4R | |
| SCHEMBL8862112 | 0.92 | LTB4R (0.83) | LTB4R | |
| SCHEMBL8075725 | 0.91 | LTB4R (0.82) | LTB4R | |
| Lithium Ion SCHEMBL7025236 | 0.91 | LTB4R (0.85) | LTB4R | |
| SCHEMBL9367640 | 0.90 | LTB4R (0.69) | LTB4R | |
| SCHEMBL9367634 | 0.90 | LTB4R (0.69) | LTB4R | |
| SCHEMBL9372956 | 0.89 | LTB4R (0.68) | LTB4R | |
| SCHEMBL9372962 | 0.89 | LTB4R (0.68) | LTB4R | |
| SCHEMBL9370936 | 0.89 | LTB4R (0.64) | LTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0812194-B1 | Use of substituted pyridine compounds for treating atopic dermatitis and contact dermatitis | SMITHKLINE BEECHAM CORP (US) | 2000-08-16 | — | — | EP | disclosed |
| US-5633258-A | Pyridine compounds for treating leukotriene-related diseases | SMITHKLINE BEECHAM CORPORATION (US) | 1997-05-27 | — | — | US | disclosed |
| US-5631262-A | Pyridine compounds for treating leukotriene-related diseases | SMITHKLINE BEECHAM CORPORATION (US) | 1997-05-20 | — | — | US | disclosed |