Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 17/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CCR2 | P41597 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15084364 | 0.84 | GAA (0.60) | GAAMAPTHTTROCK2ROCK1 | |
| SCHEMBL15081998 | 0.81 | GAA (0.57) | GAAMAPTHTTROCK2ROCK1 | |
| SCHEMBL13754467 | 0.78 | CACNA1B (0.66) | GAAMAPTHTTROCK2ROCK1 | |
| SCHEMBL14193581 | 0.76 | ROCK2 (0.57) | GAAMAPTHTTROCK2ROCK1 | |
| SCHEMBL14193590 | 0.76 | ROCK2 (0.57) | GAAMAPTHTTROCK2ROCK1 | |
| SCHEMBL14193591 | 0.74 | PRKD3 (0.56) | GAAMAPTHTTROCK2ROCK1 | |
| SCHEMBL13595600 | 0.74 | PRKD3 (0.56) | GAAMAPTHTTROCK2ROCK1 | |
| SCHEMBL14193586 | 0.74 | PRKD3 (0.56) | GAAMAPTHTTROCK2ROCK1 | |
| SCHEMBL14193587 | 0.74 | CXCR4 (0.53) | GAAMAPTHTTROCK2ROCK1 | |
| SCHEMBL13595857 | 0.74 | GAA (0.49) | GAAMAPTHTTROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012036997-A1 | FUSED PYRAZOLE DERIVATIVES AS NOVEL ERK INHIBITORS | SCHERING CORPORATION (US) | 2012-03-22 | — | — | WO | disclosed |