Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.79 |
| ▸ | DRD3 | P35462 | 1/20 | 0.79 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.67 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.62 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.62 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.62 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.55 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL266921 | 1.00 | DRD2 (0.79) | DRD2DRD3ADRA1ACHRM2CHRM1 | |
| SCHEMBL4210081 | 1.00 | DRD2 (0.79) | DRD2DRD3ADRA1ACHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL7028613 | 0.98 | DRD2 (0.77) | DRD2DRD3ADRA1ACHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL4213402 | 0.98 | DRD2 (0.77) | DRD2DRD3ADRA1ACHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL4208502 | 0.98 | DRD2 (0.77) | DRD2DRD3ADRA1ACHRM2CHRM1 | |
| SCHEMBL895845 | 0.88 | DRD2 (1.00) | DRD2DRD3ADRA1ACHRM2CHRM1 | |
| SCHEMBL895742 | 0.88 | DRD2 (1.00) | DRD2DRD3ADRA1ACHRM2CHRM1 | |
| SCHEMBL29547385 | 0.88 | DRD2 (1.00) | DRD2DRD3ADRA1ACHRM2CHRM1 | |
| SCHEMBL43366 | 0.88 | DRD2 (1.00) | DRD2DRD3ADRA1ACHRM2CHRM1 | |
| SCHEMBL29429678 | 0.88 | DRD2 (1.00) | DRD2DRD3ADRA1ACHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0683236-B1 | Enzymatic process for the preparation of optical active tetralin-derivatives | SANOFI SYNTHELABO (FR) | 2000-08-09 | — | — | EP | disclosed |
| EP-0683236-A1 | Enzymatic process for the preparation of optical active tetralin-derivatives | SANOFI (FR) | 1995-11-22 | — | — | EP | disclosed |
| US-5214156-A | Central nervous system disorders, dopamime receptor activity | THE UPJOHN COMPANY (US) | 1993-05-25 | — | — | US | disclosed |
| EP-0334538-B1 | THERAPEUTICALLY USEFUL TETRALIN DERIVATIVES | THE UPJOHN COMPANY (US) | 1992-12-02 | — | — | EP | disclosed |
| EP-0407416-A1 | THERAPEUTICALLY USEFUL TETRALIN DERIVATIVES | THE UPJOHN COMPANY (US) | 1991-01-16 | — | — | EP | disclosed |
| WO-1989009050-A1 | THERAPEUTICALLY USEFUL TETRALIN DERIVATIVES | THE UPJOHN COMPANY (US) | 1989-10-05 | — | — | WO | disclosed |
| EP-0334538-A1 | Therapeutically useful tetralin derivatives | THE UPJOHN COMPANY (US) | 1989-09-27 | — | — | EP | disclosed |