Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.57 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | FABP3 | P05413 | 7/20 | 0.48 |
| ▸ | BBOX1 | O75936 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sebacic Acid SCHEMBL17961672 | 0.97 | CA1 (0.55) | CA1FFAR3HDAC3HDAC1HDAC2 | |
| Azelaic Acid SCHEMBL7627274 | 0.97 | CA1 (0.55) | CA1FFAR3HDAC3HDAC1HDAC2 | |
| Octanedioate SCHEMBL17961688 | 0.97 | CA1 (0.55) | CA1FFAR3HDAC3HDAC1HDAC2 | |
| Glutarate SCHEMBL17961689 | 0.94 | CA1 (0.57) | CA1FFAR3HDAC3HDAC1HDAC2 | |
| Hexanoate SCHEMBL18207962 | 0.89 | CA1 (0.68) | CA1FFAR3HDAC3HDAC1HDAC2 | |
| Octanoic Acid SCHEMBL3417082 | 0.87 | FABP3 (0.67) | CA1FFAR3HDAC3HDAC1HDAC2 | |
| Dodecanoate SCHEMBL31443247 | 0.87 | FABP3 (0.67) | CA1FFAR3HDAC3HDAC1HDAC2 | |
| Heptanoate SCHEMBL18207959 | 0.87 | FABP3 (0.67) | CA1FFAR3HDAC3HDAC1HDAC2 | |
| Stearic Acid SCHEMBL5169348 | 0.87 | FABP3 (0.67) | CA1FFAR3HDAC3HDAC1HDAC2 | |
| Decanoic Acid SCHEMBL2637563 | 0.87 | FABP3 (0.67) | CA1FFAR3HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10000603-B2 | Organotin ester polymer compositions, methods of manufacture, and uses thereof | THE UNIVERSITY OF CONNECTICUT (US) | 2018-06-19 | — | — | US | claimed |
| US-20160222172-A1 | ORGANOTIN ESTER POLYMER COMPOSITIONS, METHODS OF MANUFACTURE, AND USES THEREOF | UNIV CONNECTICUT (US) | 2016-08-04 | — | — | US | claimed |
| WO-1987005037-A1 | ROOM TEMPERATURE VULCANIZABLE ORGANOPOLYSILOXANE COMPOSITIONS AND METHOD FOR MAKING | GENERAL ELECTRIC COMPANY (US) | 1987-08-27 | — | — | WO | claimed |
| US-10000603-B2 | Organotin ester polymer compositions, methods of manufacture, and uses thereof | THE UNIVERSITY OF CONNECTICUT (US) | 2018-06-19 | — | — | US | disclosed |
| US-20160222172-A1 | ORGANOTIN ESTER POLYMER COMPOSITIONS, METHODS OF MANUFACTURE, AND USES THEREOF | UNIV CONNECTICUT (US) | 2016-08-04 | — | — | US | disclosed |
| EP-0765891-B1 | Process for the preparation of water-blown integral skin polyurethane foams and catalysts useful therein | BAYER AG (US) | 2000-08-09 | — | — | EP | disclosed |
| EP-0765891-A1 | Water-blown integral skin polyurethane foams and catalysts useful therein | Bayer Corporation (US) | 1997-04-02 | — | — | EP | disclosed |
| US-5514723-A | POLYMERIZATION USING CATALYST MIXTURE OF DIORGANOTIN SULFIDE, TERTIARY AMINE, AND TIN COMPOUND | BAYER CORPORATION (US) | 1996-05-07 | — | — | US | disclosed |
| US-4855352-A | Process for the production of stable dispersions, the dispersions so produced, and the use thereof in the manufacture of polyurethanes | MOBAY CORPORATION (US) | 1989-08-08 | — | — | US | disclosed |
| WO-1987005037-A1 | ROOM TEMPERATURE VULCANIZABLE ORGANOPOLYSILOXANE COMPOSITIONS AND METHOD FOR MAKING | GENERAL ELECTRIC COMPANY (US) | 1987-08-27 | — | — | WO | disclosed |
| US-4554310-A | Room temperature vulcanizable organopolysiloxane compositions and method for making | GENERAL ELECTRIC COMPANY (US) | 1985-11-19 | — | — | US | disclosed |
| US-4353995-A | TERTIARY AMINE, TIN COMPOUND, AND BARIUM OR CALCIUM CARBOXYLATE | MOBAY CHEMICAL CORPORATION (US) | 1982-10-12 | — | — | US | disclosed |
| EP-0016355-A2 | Novel catalyst system for polyurethane foams and the use thereof | Mobay Chemical Corporation (US) | 1980-10-01 | — | — | EP | disclosed |
| US-4217247-A | TERTIARY AMINE, TIN COMPOUND, CALCIUM OR BARIUM CARBOXYLATE | MOBAY CHEMICAL CORPORATION (US) | 1980-08-12 | — | — | US | disclosed |