SCHEMBL8076349

SCHEMBL8076349

Nc1ccc(/C=N\O)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.52
ALDH1A1 P00352 4/20 0.47
KDM4E B2RXH2 2/20 0.47
GAA P10253 1/20 0.47
ACHE P22303 3/20 0.46
APP P05067 2/20 0.46
L3MBTL1 Q9Y468 1/20 0.45
MAPT P10636 3/20 0.44
MEN1 O00255 2/20 0.44
CYP19A1 P11511 3/20 0.42
MAOA P21397 1/20 0.42
MAOB P27338 1/20 0.42
GRIN2D O15399 2/20 0.41
GRIN3B O60391 2/20 0.41
GRIN1 Q05586 2/20 0.41
GRIN2A Q12879 2/20 0.41
GRIN2B Q13224 2/20 0.41
GRIN2C Q14957 2/20 0.41
GRIN3A Q8TCU5 2/20 0.41
F2 P00734 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9635204 1.00 KMT2A (0.52) KMT2AALDH1A1KDM4EGAAACHE
SCHEMBL8076350 1.00 KMT2A (0.52) KMT2AALDH1A1KDM4EGAAACHE
SCHEMBL4275683 0.86 KMT2A (0.64) KMT2AALDH1A1KDM4EGAAACHE
SCHEMBL4275687 0.86 KMT2A (0.64) KMT2AALDH1A1KDM4EGAAACHE
SCHEMBL5668373 0.86 KMT2A (0.64) KMT2AALDH1A1KDM4EGAAACHE
SCHEMBL22198279 0.78 NPC1 (0.55) KMT2AALDH1A1APPL3MBTL1MAPT
SCHEMBL2164065 0.76 ALDH1A1 (0.67) KMT2AALDH1A1KDM4EGAAACHE
SCHEMBL91114 0.76 ALDH1A1 (0.67) KMT2AALDH1A1KDM4EGAAACHE
SCHEMBL17266210 0.76 MAOB (0.61) KMT2AALDH1A1ACHEAPPL3MBTL1
SCHEMBL76630 0.76 ALDH1A1 (0.67) KMT2AALDH1A1KDM4EGAAACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0280975-B1 PROCESSES FOR THE PRODUCTION OF SUBSTITUTED BENZALDEHYDES, AND INTERMEDIATE PRODUCTS OBTAINED BY THESE PROCESSES F. HOFFMANN-LA ROCHE AG (CH) 1992-07-08 EP claimed
EP-0229641-B1 PROCESS FOR THE PREPARATION OF HYDROXYBENZALDOXIME O-ETHERS BAYER AG (DE) 1990-10-03 EP claimed
US-4845287-A Hydroxybenzaldoxime O-ethers BAYER AKTIENGESELLSCHAFT (DE) 1989-07-04 US claimed
EP-0825975-B1 PROCESS FOR THE PREPARATION OF SUBSTITUTED AROMATIC AMINO COMPOUNDS NOVARTIS AG (CH) 2000-08-23 EP disclosed
US-5877340-A Process for the preparation of substituted aromatic amino compounds NOVARTIS CONSUMER HEALTH S.A. (CH) 1999-03-02 US disclosed
EP-0825975-A1 PROCESS FOR THE PREPARATION OF SUBSTITUTED AROMATIC AMINO COMPOUNDS Novartis AG (CH) 1998-03-04 EP disclosed
WO-1996036588-A1 PROCESS FOR THE PREPARATION OF SUBSTITUTED AROMATIC AMINO COMPOUNDS NOVARTIS AG (CH) 1996-11-21 WO disclosed
US-4845287-A Hydroxybenzaldoxime O-ethers BAYER AKTIENGESELLSCHAFT (DE) 1989-07-04 US disclosed
US-4739119-A Process for the preparation of hydroxybenzaldoxime O-ethers BAYER AKTIENGESELLSCHAFT (DE) 1988-04-19 US disclosed
EP-0050285-A1 Incorporable reactive blowing agents containing mixtures of polyols, and their use in the production of foamed polyurethanes BAYER AG (DE) 1982-04-28 EP disclosed