Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | SRC | P12931 | 2/20 | 0.56 |
| ▸ | EGFR | P00533 | 6/20 | 0.54 |
| ▸ | ABL1 | P00519 | 3/20 | 0.54 |
| ▸ | ABL2 | P42684 | 2/20 | 0.54 |
| ▸ | CDK1 | P06493 | 1/20 | 0.53 |
| ▸ | PRKCA | P17252 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8084587 | 0.91 | KMT2A (0.67) | MEN1KMT2ANPC1RAB9ANR2F2 | |
| SCHEMBL8076462 | 0.88 | KMT2A (0.63) | MEN1KMT2ANPC1RAB9ANR2F2 | |
| SCHEMBL8088051 | 0.88 | MEN1 (0.63) | MEN1KMT2ANPC1RAB9ANR2F2 | |
| SCHEMBL17609367 | 0.83 | POLB (0.67) | MEN1KMT2ANPC1RAB9ANR2F2 | |
| SCHEMBL17406893 | 0.82 | KMT2A (0.65) | MEN1KMT2ANPC1RAB9ANR2F2 | |
| SCHEMBL8129590 | 0.80 | SRC (0.58) | MEN1KMT2AKDM4ETSHRHTT | |
| SCHEMBL13064030 | 0.79 | MAPT (0.62) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL8121867 | 0.79 | MAPT (0.62) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL7497953 | 0.79 | EGFR (0.54) | MEN1KMT2ANPC1KDM4ETSHR | |
| SCHEMBL8123792 | 0.79 | SRC (0.57) | MEN1KMT2AKDM4ETSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6096749-A | ANTITUMOR, EPIDERMAL GROWTH FACTOR | NOVARTIS CORPORATION (US) | 2000-08-01 | — | — | US | disclosed |
| EP-0682027-B1 | Pyrrolopyrimidine derivatives with antiproliferative action | CIBA GEIGY AG (CH) | 1997-10-15 | — | — | EP | disclosed |
| EP-0682027-A1 | Pyrrolopyrimidine derivatives with antiproliferative action | CIBA-GEIGY AG (CH) | 1995-11-15 | — | — | EP | disclosed |