Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 11/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | FPR3 | P25089 | 1/20 | 0.38 |
| ▸ | FPR2 | P25090 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL242088 | 0.76 | USP30 (0.68) | USP30HDAC4HDAC6PARP1GPR119 | |
| SCHEMBL242087 | 0.76 | USP30 (0.68) | USP30HDAC4HDAC6PARP1GPR119 | |
| SCHEMBL6200199 | 0.70 | USP30 (0.69) | USP30HDAC4HDAC6PARP1GPR119 | |
| SCHEMBL6200204 | 0.70 | USP30 (0.69) | USP30HDAC4HDAC6PARP1GPR119 | |
| SCHEMBL28975873 | 0.69 | HDAC4 (0.60) | USP30HDAC4HDAC6PARP1NPC1 | |
| SCHEMBL640458 | 0.69 | ALDH1A1 (0.61) | USP30NPC1RAB9AGPR119FPR3 | |
| SCHEMBL640457 | 0.69 | ALDH1A1 (0.61) | USP30NPC1RAB9AGPR119FPR3 | |
| SCHEMBL807196 | 0.68 | — | — | |
| SCHEMBL18741673 | 0.67 | USP30 (0.51) | USP30PARP1NPC1RAB9AGPR119 | |
| SCHEMBL18741675 | 0.67 | USP30 (0.51) | USP30PARP1NPC1RAB9AGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012036997-A1 | FUSED PYRAZOLE DERIVATIVES AS NOVEL ERK INHIBITORS | SCHERING CORPORATION (US) | 2012-03-22 | — | — | WO | disclosed |