Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | CCND1 | P24385 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.41 |
| ▸ | CLK2 | P49760 | 2/20 | 0.41 |
| ▸ | CLK3 | P49761 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2416166 | 0.76 | PCSK9 (0.56) | CDK2CDK1CDK4CCND1HRH3 | |
| SCHEMBL8061114 | 0.76 | CDK2 (0.42) | CDK2CDK1CDK4CCND1HRH3 | |
| Hydrochloric Acid SCHEMBL2416162 | 0.75 | PCSK9 (0.55) | CDK2CDK1CDK4CCND1HRH3 | |
| SCHEMBL14961898 | 0.75 | PDGFRB (0.46) | PDGFRBPDGFRAEGFRINSRLCK | |
| SCHEMBL4233677 | 0.74 | HCAR3 (0.56) | CDK2CDK1CDK4CCND1HRH3 | |
| SCHEMBL614867 | 0.73 | ATR (0.47) | CDK2CDK1CDK4CCND1HRH4 | |
| SCHEMBL8077031 | 0.72 | KDM4E (0.55) | — | |
| SCHEMBL12248189 | 0.72 | NPSR1 (0.47) | IRAK4 | |
| SCHEMBL31584450 | 0.72 | ATR (0.42) | — | |
| SCHEMBL30062337 | 0.70 | PRMT5 (0.48) | HRH3HRH4CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6156758-A | Antibacterial quinazoline compounds | ISIS PHARMACEUTICALS, INC. (US) | 2000-12-05 | — | — | US | disclosed |