SCHEMBL8077189

SCHEMBL8077189

Cc1c(Cl)n[nH]c1C(=O)O

nearest known ligand 0.44

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 5/20 0.44
DAO P14920 1/20 0.36
ALDH1A1 P00352 2/20 0.35
HPGD P15428 1/20 0.35
TSHR P16473 1/20 0.35
MAPK1 P28482 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
BDKRB1 P46663 1/20 0.33
HCAR3 P49019 1/20 0.33
RAB9A P51151 1/20 0.33
HSP90AA1 P07900 1/20 0.31
PDK2 Q15119 1/20 0.31
GPR35 Q9HC97 2/20 0.31
ALPL P05186 2/20 0.30
PTK2 Q05397 1/20 0.30
CA12 O43570 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15824828 0.77 DYRK1A (0.44) HCAR2DAOALDH1A1HPGDTSHR
SCHEMBL14879418 0.74 HCAR2 (0.48) HCAR2DAOALDH1A1HPGDTSHR
SCHEMBL31469596 0.74 HCAR2 (0.37) HCAR2DAOALDH1A1HPGDTSHR
SCHEMBL1754228 0.74 HCAR2 (0.37) HCAR2DAOALDH1A1HCAR3RAB9A
SCHEMBL15648066 0.74 JAK2 (0.41) HCAR2ALDH1A1HPGDTSHRALPL
SCHEMBL2589542 0.71 HCAR2 (0.47) HCAR2DAOALDH1A1HCAR3RAB9A
SCHEMBL7261697 0.71 HCAR2 (0.35) HCAR2DAOALDH1A1HPGDHCAR3
SCHEMBL9786738 0.71
SCHEMBL6111067 0.69 HCAR2 (0.38) HCAR2DAOHCAR3RAB9A
SCHEMBL6109414 0.69 HCAR2 (0.36) HCAR2DAOHCAR3RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0757987-B1 Pyrazole-carboxylic acid derivatives as plant disease control agents NISSAN CHEMICAL IND LTD (JP) 2000-07-19 EP disclosed