Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | VNN1 | O95497 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MC4R | P32245 | 1/20 | 0.46 |
| ▸ | MC3R | P41968 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4310873 | 0.88 | ALOX5 (0.56) | ALOX5MEN1KMT2ANR1H4CYP1A2 | |
| SCHEMBL21705053 | 0.83 | NR1H4 (0.58) | ALOX5MEN1KMT2ANR1H4CYP1A2 | |
| SCHEMBL6341622 | 0.83 | ALOX5 (0.51) | ALOX5MEN1KMT2ANR1H4CYP1A2 | |
| SCHEMBL11634753 | 0.82 | ALOX5 (0.50) | ALOX5MEN1KMT2ANR1H4CYP1A2 | |
| SCHEMBL3892546 | 0.82 | CYP1A2 (0.50) | ALOX5MEN1KMT2ANR1H4CYP1A2 | |
| SCHEMBL13061973 | 0.81 | CYP1A2 (0.57) | ALOX5MEN1KMT2ANR1H4CYP1A2 | |
| SCHEMBL29651866 | 0.81 | ALOX5 (0.53) | ALOX5MEN1KMT2ANR1H4CYP1A2 | |
| SCHEMBL1020432 | 0.81 | ALOX5 (0.53) | ALOX5MEN1KMT2ANR1H4CYP1A2 | |
| SCHEMBL5403251 | 0.80 | ALOX5 (0.49) | ALOX5MEN1KMT2ANR1H4CYP1A2 | |
| Methane SCHEMBL28079584 | 0.79 | ALOX5 (0.51) | ALOX5MEN1KMT2ANR1H4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968209-A1 | THIAZOLE BENZENESULFONAMIDES AS $g(b) 3? AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY | Merck & Co., Inc. (US) | 2000-01-05 | — | — | EP | disclosed |
| US-6011048-A | Thiazole benzenesulfonamides as β3 agonists for treatment of diabetes and obesity | MERCK & CO., INC. (US) | 2000-01-04 | — | — | US | disclosed |
| WO-1998032753-A1 | THIAZOLE BENZENESULFONAMIDES AS β3 AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY | MERCK & CO., INC. (US) | 1998-07-30 | — | — | WO | disclosed |