Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | UGT2B7 | P16662 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13024948 | 0.92 | AOC3 (0.49) | CYP1A2CYP2D6AOC3TSHRMEN1 | |
| SCHEMBL8080159 | 0.88 | TRPM8 (0.46) | UTS2RBCHEHDAC1 | |
| SCHEMBL17073786 | 0.85 | CYP2D6 (0.44) | CYP2D6TSHRUTS2RBCHEPOLB | |
| SCHEMBL8080511 | 0.84 | AOC3 (0.54) | CYP1A2CYP2D6AOC3TSHRMEN1 | |
| SCHEMBL8060864 | 0.82 | AOC3 (0.48) | CYP1A2CYP2D6AOC3TSHRMEN1 | |
| SCHEMBL13025061 | 0.82 | AOC3 (0.48) | CYP1A2CYP2D6AOC3TSHRMEN1 | |
| SCHEMBL2888672 | 0.82 | AOC3 (0.48) | CYP1A2CYP2D6AOC3TSHRMEN1 | |
| SCHEMBL8080532 | 0.81 | AOC3 (0.47) | CYP1A2CYP2D6AOC3TSHRMEN1 | |
| SCHEMBL20050149 | 0.80 | AOC3 (0.59) | CYP1A2CYP2D6AOC3TSHRMEN1 | |
| SCHEMBL13066675 | 0.78 | AOC3 (0.43) | CYP1A2CYP2D6AOC3TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100286164-A1 | SUBSTITUTED ARYL ALKYLAMINO-OXY-ANALOGS AND USES THEREOF | THE BRIGHAM AND WOMEN'S HOSPITAL, INC (US) | 2010-11-11 | — | — | US | disclosed |
| US-20100286164-A1 | SUBSTITUTED ARYL ALKYLAMINO-OXY-ANALOGS AND USES THEREOF | THE BRIGHAM AND WOMEN'S HOSPITAL, INC (US) | 2010-11-11 | — | — | US | disclosed |
| WO-2009051661-A2 | SUBSTITUTED ARYL ALKYLAMINO-OXY-ANALOGS AND USES THEREOF | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2009-04-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286164-A1 | SUBSTITUTED ARYL ALKYLAMINO-OXY-ANALOGS AND USES THEREOF | BACE1, BACE2, APP | CYP1A2 259/4885CYP2D6 1100/4885AOC3 129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.