Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 10/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 10/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.38 |
| ▸ | C5 | P01031 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.38 |
| ▸ | PFKFB4 | Q16877 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | CDC42 | P60953 | 1/20 | 0.38 |
| ▸ | RAC1 | P63000 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7821349 | 0.73 | APP (0.53) | AKR1C3AKR1C2PTGS2PTGS1MEN1 | |
| SCHEMBL8082759 | 0.72 | AKR1C3 (0.47) | AKR1C3AKR1C2PTGS2PTGS1MEN1 | |
| SCHEMBL12726877 | 0.69 | AKR1B1 (0.58) | AKR1C3AKR1C2PTGS2PTGS1MEN1 | |
| SCHEMBL31256676 | 0.69 | AKR1B1 (0.58) | AKR1C3AKR1C2PTGS2PTGS1MEN1 | |
| SCHEMBL6984620 | 0.69 | AKR1C3 (0.49) | AKR1C3AKR1C2PTGS2PTGS1MEN1 | |
| SCHEMBL2945363 | 0.68 | CMA1 (0.44) | MEN1MAPTKMT2APFKFB3PFKFB4 | |
| SCHEMBL11248448 | 0.67 | AKR1B1 (0.55) | AKR1C3AKR1C2PTGS2PTGS1MEN1 | |
| SCHEMBL9756996 | 0.67 | ROCK1 (0.33) | — | |
| SCHEMBL9613234 | 0.67 | PFKFB3 (0.56) | PFKFB3PFKFB4 | |
| SCHEMBL4432509 | 0.66 | AKR1C3 (0.44) | AKR1C3AKR1C2PTGS2PTGS1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882066-B1 | PEPTIDE DERIVATIVES | ZENECA LTD (GB) | 2000-09-06 | — | — | EP | disclosed |
| US-6087336-A | ANTIINFLAMMATORY AGENT TREATING RHEUMATOID ARTHRITIS | ZENECA LIMITED (GB) | 2000-07-11 | — | — | US | disclosed |
| EP-0882066-A1 | PEPTIDE DERIVATIVES | ZENECA LIMITED (GB) | 1998-12-09 | — | — | EP | disclosed |
| WO-1997031023-A1 | PEPTIDE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-28 | — | — | WO | disclosed |