Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.55 |
| ▸ | APP | P05067 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | FABP2 | P12104 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7821349 | 0.91 | APP (0.53) | AKR1B1APPPTGS2AKR1C3AKR1C2 | |
| SCHEMBL31256676 | 0.84 | AKR1B1 (0.58) | AKR1B1APPPTGS2AKR1C3AKR1C2 | |
| SCHEMBL12726877 | 0.84 | AKR1B1 (0.58) | AKR1B1APPPTGS2AKR1C3AKR1C2 | |
| SCHEMBL11235648 | 0.82 | PTGS2 (0.60) | PTGS2PTGS1MAPTMEN1KMT2A | |
| SCHEMBL11238632 | 0.81 | GABRP (0.50) | MAPTMEN1KMT2AHPGDLMNA | |
| SCHEMBL8610327 | 0.80 | ALDH1A1 (0.50) | MAPTMEN1KMT2AHPGDCYP1A2 | |
| SCHEMBL13338346 | 0.80 | GPR3 (0.54) | PTGS1MAPTHPGDLMNASMN1; SMN2 | |
| SCHEMBL23008021 | 0.79 | MAPT (0.49) | APPMAPTMEN1KMT2AHPGD | |
| SCHEMBL22591613 | 0.79 | MAPT (0.49) | MAPTMEN1KMT2AHPGDLMNA | |
| SCHEMBL25721015 | 0.77 | ALDH1A1 (0.50) | MAPTMEN1KMT2AHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4334078-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIRHEUMATICS | HOFFMANN-LA ROCHE INC. (US) | 1982-06-08 | — | — | US | disclosed |
| US-4219657-A | USED AS ANTIINFLAMATORY AGENTS, ANALGESICS, ANTIRHEUMATIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1980-08-26 | — | — | US | disclosed |