Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 16/20 | 0.38 |
| ▸ | PRKDC | P78527 | 16/20 | 0.38 |
| ▸ | ATR | Q13535 | 15/20 | 0.38 |
| ▸ | ATRIP | Q8WXE1 | 14/20 | 0.38 |
| ▸ | ATM | Q13315 | 11/20 | 0.38 |
| ▸ | MTOR | P42345 | 10/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.36 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.36 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
| ▸ | LTK | P29376 | 1/20 | 0.36 |
| ▸ | CDK7 | P50613 | 1/20 | 0.36 |
| ▸ | NEK2 | P51955 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL807986 | 0.90 | PRKDC (0.38) | PIK3CBPRKDCATRATRIPATM | |
| SCHEMBL15131796 | 0.84 | MTOR (0.49) | PIK3CBPRKDCATRATRIPATM | |
| SCHEMBL15131800 | 0.83 | PIK3CB (0.42) | PIK3CBPRKDCATRATRIPATM | |
| SCHEMBL807826 | 0.82 | PI4KA (0.45) | PIK3CBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL15131797 | 0.82 | PIK3CB (0.42) | PIK3CBPRKDCATRATRIPATM | |
| SCHEMBL15131811 | 0.81 | MTOR (0.38) | PIK3CBPRKDCATRATRIPATM | |
| SCHEMBL15133610 | 0.81 | PIK3CB (0.41) | PIK3CBPRKDCATRATRIPATM | |
| SCHEMBL796792 | 0.81 | MTOR (0.38) | PIK3CBPRKDCATRATRIPATM | |
| SCHEMBL15133602 | 0.80 | MTOR (0.39) | PIK3CBPRKDCATRATRIPATM | |
| SCHEMBL10070631 | 0.80 | MTOR (0.38) | PIK3CBPRKDCATRATRIPATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9181264-B2 | Fused heteroaryls and their uses | HUTCHISON MEDIPHARMA LIMITED (CN) | 2015-11-10 | — | — | US | disclosed |
| US-20130190307-A1 | FUSED HETEROARYLS AND THEIR USES | HUTCHISON MEDIPHARMA LIMITED (CN) | 2013-07-25 | — | — | US | disclosed |
| WO-2012034526-A1 | FUSED HETEROARYLS AND THEIR USES | HUTCHISON MEDIPHARMA LIMITED (CN) | 2012-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130190307-A1 | FUSED HETEROARYLS AND THEIR USES | FARS2, TIAL1, DHFR | PIK3CB 1750/4885PRKDC 3135/4885ATR 3548/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.