Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 18/20 | 0.46 |
| ▸ | PSMB8 | P28062 | 5/20 | 0.43 |
| ▸ | PSMB9 | P28065 | 4/20 | 0.43 |
| ▸ | PSMB1 | P20618 | 4/20 | 0.43 |
| ▸ | PSMB11 | A5LHX3 | 3/20 | 0.43 |
| ▸ | PSMA7 | O14818 | 3/20 | 0.43 |
| ▸ | PSMA1 | P25786 | 3/20 | 0.43 |
| ▸ | PSMA2 | P25787 | 3/20 | 0.43 |
| ▸ | PSMA3 | P25788 | 3/20 | 0.43 |
| ▸ | PSMA4 | P25789 | 3/20 | 0.43 |
| ▸ | PSMA5 | P28066 | 3/20 | 0.43 |
| ▸ | PSMB4 | P28070 | 3/20 | 0.43 |
| ▸ | PSMB6 | P28072 | 3/20 | 0.43 |
| ▸ | PSMB10 | P40306 | 3/20 | 0.43 |
| ▸ | PSMB3 | P49720 | 3/20 | 0.43 |
| ▸ | PSMB2 | P49721 | 3/20 | 0.43 |
| ▸ | PSMA6 | P60900 | 3/20 | 0.43 |
| ▸ | PSMA8 | Q8TAA3 | 3/20 | 0.43 |
| ▸ | PSMB7 | Q99436 | 3/20 | 0.43 |
| ▸ | LONP1 | P36776 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8076514 | 0.94 | PSMB5 (0.45) | PSMB5PSMB8PSMB9PSMB1PSMB11 | |
| SCHEMBL8079474 | 0.94 | PSMB5 (0.45) | PSMB5PSMB8PSMB9PSMB1PSMB11 | |
| SCHEMBL464437 | 0.76 | PSMB5 (0.54) | PSMB5PSMB8PSMB9PSMB1PSMB11 | |
| SCHEMBL8076834 | 0.72 | PSMB5 (0.49) | PSMB5PSMB8PSMB9PSMB1PSMB11 | |
| SCHEMBL10952773 | 0.72 | PSMB5 (0.56) | PSMB5PSMB8PSMB9PSMB1PSMB11 | |
| SCHEMBL13656745 | 0.72 | ALDH1A1 (0.39) | — | |
| SCHEMBL12340797 | 0.72 | DPP8 (0.62) | PSMB5PSMB8PSMB9PSMB1PSMB11 | |
| SCHEMBL12340807 | 0.72 | PSMB5 (0.60) | PSMB5PSMB8PSMB9PSMB1PSMB11 | |
| SCHEMBL21558113 | 0.71 | PSMB5 (0.54) | PSMB5PSMB8PSMB9PSMB1PSMB11 | |
| SCHEMBL8083600 | 0.70 | PSMB5 (0.51) | PSMB5PSMB8PSMB9PSMB1PSMB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009051581-A1 | PROTEASOME INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-04-23 | — | — | WO | disclosed |